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Disperse tablet for activating bood and stopping pain and its preparation

A technology of promoting blood circulation and relieving pain, dispersible tablets, applied in the direction of inorganic active ingredients, non-central analgesics, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2006-05-31
大道隆达(北京)医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a kind of raw medicinal material powder without extracting the Huoxuezhipain Dispersible Tablet directly made, which solves the problem of powder, capsule and other preparations made by extraction methods, and has the following characteristics: 1. The disintegration time is short, Good dispersion state, avoiding the aggregation of the original drug powder in powder and capsule into agglomerates in liquid, the active ingredient dissolves more quickly; 2, fast absorption, high bioavailability, 3, good taste, easy to take, can be swallowed, chewed and contains Suck or disperse with water before taking

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Angelica 400g

[0019] Panax notoginseng 80g

[0020] Frankincense (made) 80g

[0021] ice flakes 20g

[0022] Ground Beetle 200g

[0023] Natural copper (calcined) 120g

[0024] Microcrystalline Cellulose 100g

[0025] Sodium carboxymethyl starch 200g

[0026] 2% hypromellose appropriate amount

[0027] Aspartame 2g

[0028] Lemon essence 2g

[0029] Magnesium Stearate 10g

[0030] A total of 1200 pieces were made

[0031] Preparation method:

[0032] 1. Crush the other five flavors except borneol into fine powder, grind borneol into fine powder, mix with the above powder, pass through a 100-mesh sieve, and mix well.

[0033] 2. Take hypromellose and add water to make a 2% solution.

[0034] 3. The original medicinal material powder, microcrystalline cellulose and sodium carboxymethyl starch half of the prescription amount are passed through a 100-mesh sieve and mixed evenly, and the soft material is made of 2% hypromellose. Granulate with a 20-mesh sieve,...

Embodiment 2

[0036] Angelica 400g

[0037] Panax notoginseng 80g

[0038] Frankincense (made) 80g

[0039] ice flakes 20g

[0040] Ground Beetle 200g

[0041] Natural copper (calcined) 120g

[0042] Microcrystalline Cellulose 900g

[0043] Crospovidone 100g

[0044] 5% povidone appropriate amount

[0045] Aspartame 4g

[0046] Lemon essence 4g

[0047] Magnesium Stearate 20g

[0048] A total of 2400 pieces were made

[0049] Preparation method:

[0050] 1. Crush the other five flavors except borneol into fine powder, grind borneol into fine powder, mix with the above powder, pass through a 100-mesh sieve, and mix well.

[0051] 2. Take povidone and add water to make a 5% solution.

[0052] 3. The raw medicinal material powder, microcrystalline cellulose, and crospovidone are passed through a 100-mesh sieve, mixed evenly, and soft material is made with 5% povidone. Granulate with a 20-mesh sieve, dry at 50°C for 20 minutes, and granulate with a 20-mesh sieve. Add aspartame, le...

Embodiment 3

[0054] Angelica 400g

[0055] Panax notoginseng 80g

[0056] Frankincense (made) 80g

[0057] ice flakes 20g

[0058] Ground Beetle 200g

[0059] Natural copper (calcined) 120g

[0060] Microcrystalline Cellulose 400g

[0061] Croscarmellose Sodium 60g

[0062] 2% hypromellose appropriate amount

[0063] Aspartame 3g

[0064] Lemon essence 3g

[0065] Magnesium Stearate 15g

[0066] A total of 2400 pieces were made

[0067] Preparation method: 1. Grind the other five flavors except borneol into fine powder, grind borneol into fine powder, mix with the above powder, pass through a 100-mesh sieve, and mix well.

[0068] 2. Take hypromellose and add water to make a 2% solution.

[0069] 3. Pass through a 100-mesh sieve, the original medicinal material powder, microcrystalline cellulose, and croscarmellose sodium, mix well, and make a soft material with 2% hypromellose. Granulate with a 20-mesh sieve, dry at 50°C for 20 minutes, and granulate with a 20-mesh sieve. Add...

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PUM

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Abstract

A Chinese medicine in the form of dispersing tablet for activating blood to relieve pain is prepared from 6 Chinese-medicinal materials including Chinese angelica root, notoginseng, borneol, ground bettle, etc. Its advantages are high disintegrating speed and high biologic utilization rate.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, specifically a dispersible tablet preparation composed of six traditional Chinese medicines of angelica, notoginseng, frankincense, borneol, wood beetle and natural copper. Meanwhile, the invention also relates to a preparation method of the preparation. Background technique [0002] Currently, there are Huoxuezhitong San (Chinese Pharmacopoeia 2000 edition) and Huoxuezhitong Capsules (Twelfth Volume of Traditional Chinese Medicine Prescriptions) available on the market. The method of taking Huoxue Zhitong Powder is to take it with warm rice wine or warm boiled water. However, since the dosage form is made by directly crushing the medicinal materials, the liquid medicinal powder will gather into agglomerates, which is inconvenient to take and has a bad taste. absorb. Huoxuezhitong Capsules is to directly pack the medicinal material powder into the capsule shell. Although the problem ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/324A61K9/20A61K33/34A61K35/64A61P29/00
Inventor 张成飞
Owner 大道隆达(北京)医药科技发展有限公司