Double-layered medicine tablets for eliminating Helicobacter pylori and its prepn. method

A Helicobacter pylori, double-layer tablet technology, applied in the field of pharmaceutical preparations, can solve problems such as difficulty in swallowing, unfavorable large-scale production and application, and large shape, and achieve stable quality, which is conducive to large-scale industrial production and has a long storage period.

Inactive Publication Date: 2006-06-14
SHANDONG BESTCOMM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But this kind of double-layer capsule also has some defects: firstly, the outer layer is 0+ capsule,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0033] Example 1

[0034] Name of raw materials

[0035] Metronidazole

[0036] Preparation method: Weigh the prescribed amount of tetracycline hydrochloride, microcrystalline cellulose, and crospovidone, mix them and use 5% povidone solution to make a soft material, granulate, dry, and add the prescribed amount of micropowder after sizing Silica gel, magnesium stearate, mix well and compress. Take the veggie tablets, sieve to remove the fine powder, place in a coating pan, and coat the veggie tablets with a commercially available gastric-soluble Opadry 10% aqueous solution, the coating amount is about 5mg / cm 2 . Weigh the prescription amount of metronidazole, bismuth potassium citrate, microcrystalline cellulose, and crospovidone and mix them evenly, then use 5% hypromellose solution to make soft material, granulate, dry, and size. The prescription amount of poloxamer, micronized silica gel, and magnesium stearate are added and mixed thoroughly, and the first ...

Example Embodiment

[0037] Example 2

[0038] Name of raw materials

[0039] Tetracycline Hydrochloride

[0040] Eudragit E100

[0041] Preparation method: Weigh the prescription amount of metronidazole, bismuth potassium citrate, lactose, and crospovidone and mix them uniformly, prepare soft material with 5% povidone solution, granulate, dry, size, and add to the prescription Mix finely powdered silica gel and magnesium stearate thoroughly, and compress the tablets. Take the veggie tablets, sieve to remove the fine powder, place them in a coating pan, and coat the veggie tablets with the above coating liquid, the coating amount is about 4mg / cm 2. Weigh the calcinated hydrochloride, microcrystalline cellulose, lactose, crosslinked polyethylin, mixed with 5% hydroxyproplatine solution, dry, fine particles after mixing with 5% hydroxypropylttullaine solution, micro-powder silica gel, hard Magnesium magnesium, mixed, the first sheet of the package having the discharged coat...

Example Embodiment

[0042] Example 3

[0043] Name of raw materials

[0044] Metronidazole

[0045] Hydroxypropyltellel 5 MPa.s

[0046] Preparation method: Weighted tetracyclines, microcrystalline cellulose, lactose, mixed with 5% hydroxypropylttullastulose solution, formulated, granulated, dried, and intra-granulated after mixing. Sodium starch, fine powder silica, magnesium stearate, mix, tablet. Use the above-mentioned coating liquid package, the coating is about 3 mg / cm 2 . It is proud of the metronidazole, and the citrate potassium citrate and the excipient are mixed with the first layer of the coating to the second layer of particles into a double sheet. Using the above-described coating liquid coating, the coating is about 18 mg / cm 2 .

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PUM

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Abstract

A dual-layer tablet for treating the pylorospirobacillus is composed of the first layer containing the soluble salt of Bi and the first antibiotic composition and the second layer containing the second antibiotic composition. Its preparing process includes such steps as preparing the first layer, coating, preparing the second layer and combining them together by pressing.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a double-layer tablet composed of active ingredients in the compound treatment for eradicating Helicobacter pylori. And the preparation method of above-mentioned bilayer tablet. Background technique [0002] It has been 20 years since Helicobacter pylori (HP) was discovered. With a large number of studies, it has been found that HP infection is an important cause of type B chronic gastritis and is closely related to the pathogenesis of peptic ulcer. 90-100% of patients with duodenal ulcer and 60-100% of patients with gastric ulcer are infected with HP, and the total incidence of peptic ulcer accounts for about 10-20% of the population. [0003] Once H. pylori infection is confirmed, eradication therapy should be prescribed for all patients with a history of ulcers. A single treatment is not curable. If patients receive short-term acid suppression therapy w...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K33/24A61K45/06A61P1/04A61P31/04
Inventor 孟凡清刘理南李斌
Owner SHANDONG BESTCOMM PHARMA CO LTD
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