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Double-layered medicine tablets for eliminating Helicobacter pylori and its prepn. method

A Helicobacter pylori, double-layer tablet technology, applied in the field of pharmaceutical preparations, can solve problems such as difficulty in swallowing, unfavorable large-scale production and application, and large shape, and achieve stable quality, which is conducive to large-scale industrial production and has a long storage period.

Inactive Publication Date: 2006-06-14
SHANDONG BESTCOMM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But this kind of double-layer capsule also has some defects: firstly, the outer layer is 0+ capsule, which is huge in shape and difficult to swallow
This is not conducive to large-scale production applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Name of raw material

[0035] Metronidazole

[0036] Preparation method: Weigh tetracycline hydrochloride, microcrystalline cellulose, and cross-linked povidone in the prescribed amount, mix well and use 5% povidone solution to make a soft material, granulate, dry, and add the prescribed amount of micropowder after granulation Silica gel, magnesium stearate, mixed evenly, compressed into tablets. Take the plain tablet, sieve off the fine powder, put it in the coating pan, and coat the plain tablet with a 10% aqueous solution of gastric-soluble Opadry, the coating amount is about 5mg / cm 2 . After weighing metronidazole, bismuth potassium citrate, microcrystalline cellulose, and crospovidone in the prescribed amount and mix them uniformly, use 5% hypromellose solution to make a soft material, granulate, dry, and granulate. Add the prescribed amount of poloxamer, micropowder silica gel, and magnesium stearate and mix thoroughly, and press the above-men...

Embodiment 2

[0038] Name of raw material

[0039] tetracycline hydrochloride

[0040] Eudragit E100

[0041] Preparation method: Weigh metronidazole, bismuth potassium citrate, lactose, and cross-linked povidone and mix evenly, then use 5% povidone solution to make a soft material, granulate, dry, granulate, and add to the prescription Measure micronized silica gel and magnesium stearate, mix thoroughly, and press into tablets. Take the plain tablet, sieve off the fine powder, put it in the coating pan, and coat the plain tablet with the above-mentioned coating solution, the coating amount is about 4mg / cm 2. Weigh tetracycline hydrochloride, microcrystalline cellulose, lactose, and crospovidone in the prescription amount, mix them and make granules with 5% hypromellose solution, dry them, and add the micropowder silica gel and stearin in the prescription amount after granulation Magnesium acid, mixed evenly, the above-mentioned first sheet layer and the secon...

Embodiment 3

[0043] Name of raw material

[0044] Metronidazole

[0045] Hypromellose 5mPa.S

[0046] Preparation method: Weigh tetracycline hydrochloride, microcrystalline cellulose and lactose in the prescribed amount, mix well and make soft material with 5% hypromellose solution, granulate, dry, add carboxymethyl carboxymethyl in the prescribed amount after granulation Sodium starch, micronized silica gel, magnesium stearate, mixed evenly, compressed into tablets. Use the above coating solution to coat the isolation coat, and the coating amount is about 3mg / cm 2 . The prescribed amount of metronidazole, bismuth potassium citrate and auxiliary materials are evenly weighed, and the above-mentioned coated first-layer tablet and second-layer granule are pressed into a double-layer tablet. Use the above coating solution to coat the film, the coating amount is about 18mg / cm 2 .

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Abstract

A dual-layer tablet for treating the pylorospirobacillus is composed of the first layer containing the soluble salt of Bi and the first antibiotic composition and the second layer containing the second antibiotic composition. Its preparing process includes such steps as preparing the first layer, coating, preparing the second layer and combining them together by pressing.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a double-layer tablet composed of active ingredients in the compound treatment for eradicating Helicobacter pylori. And the preparation method of above-mentioned bilayer tablet. Background technique [0002] It has been 20 years since Helicobacter pylori (HP) was discovered. With a large number of studies, it has been found that HP infection is an important cause of type B chronic gastritis and is closely related to the pathogenesis of peptic ulcer. 90-100% of patients with duodenal ulcer and 60-100% of patients with gastric ulcer are infected with HP, and the total incidence of peptic ulcer accounts for about 10-20% of the population. [0003] Once H. pylori infection is confirmed, eradication therapy should be prescribed for all patients with a history of ulcers. A single treatment is not curable. If patients receive short-term acid suppression therapy w...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K33/24A61K45/06A61P1/04A61P31/04
Inventor 孟凡清刘理南李斌
Owner SHANDONG BESTCOMM PHARMA CO LTD
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