Pharmaceutical composition of sodium houttuyfonate for treating respiratory infection and preparation method thereof

A new technology of sodium houttuyniacin and composition, which is applied in the directions of drug combination, respiratory system diseases, anhydride/acid/halide active ingredients, etc., can solve the problems of affecting the curative effect, side effects, insoluble in water, etc., and achieve clinical use Safe, high clarity, good solubility

Inactive Publication Date: 2006-07-26
周艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to solve the problem of not being easily soluble in water, a large amount of Tween-80 and β-cyclodextrin (series) are mainly added to the injection as co-solvents. Excessive addition of the above excipients will not only affect the curative effect but also exist certain side effects

Method used

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  • Pharmaceutical composition of sodium houttuyfonate for treating respiratory infection and preparation method thereof
  • Pharmaceutical composition of sodium houttuyfonate for treating respiratory infection and preparation method thereof
  • Pharmaceutical composition of sodium houttuyfonate for treating respiratory infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Weigh 15 g of poloxamer, put it in 150 ml of water for injection, stir and dissolve, add sodium bisulfite to adjust the pH, and take another 1 g of neohouttuydin sodium, add it to the above poloxamer solution, and stir for 30 Minutes later, add 7.5g of mannitol, stir to dissolve, add water for injection to 250ml, mix well, filter with a 0.22μm filter membrane, divide the obtained solution into vials, 1ml each, freeze-dry to obtain new Houttuynia cordata Sodium lyophilized powder for injection (4mg each).

Embodiment 2

[0029] Example 2: Weigh 30 g of poloxamer, put it in 150 ml of water for injection, stir to dissolve, add sodium bisulfite to adjust the pH, and take another 1 g of neohouttuydin sodium, add it to the above poloxamer solution, and stir for 30 Minutes later, add 8g of lactose, stir to dissolve, add water for injection to 250ml, mix well, filter with a 0.22μm filter membrane, the resulting solution is divided into vials, 5ml each, freeze-dried to obtain new Houttuyniatin Sodium Freeze-dried powder for injection (20mg each).

Embodiment 3

[0030] Example 3: Weigh 50 g of poloxamer, put it in 250 ml of water for injection, stir to dissolve, add sodium bisulfite to adjust the pH, and take another 3 g of neohouttuydin sodium, add it to the above poloxamer solution, and stir for 30 Minutes, add 10g of molecular dextran, heat and stir to dissolve, add water for injection to 300ml, mix well, filter with 0.22μm filter membrane, and divide the obtained solution into vials, each 1ml. Freeze-drying to obtain new houttuyfonate sodium freeze-dried powder injection (10 mg each).

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PUM

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Abstract

The invention relates to a sodium new houttuyfonate pharmaceutical composition for treating respiratory tract infection and process for preparation, wherein the pharmaceutical composition comprises sodium new houttuyninum, Poloxamer or Tween-80, the preparing process comprises dissolving Poloxamer or Tween-80 into water, charging sodium hydrogen sulfite to adjust PH to 1.5-8.5, charging sodium new houttuyninum, mixing and charging excipient, isotonic agent. The dosages types include small liquid drug injections, freeze-dried powder injections, asepsis split charged powder injections, high capacity injections or fluid infusions.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition of neohouttuyfonate sodium for treating respiratory tract infection and a preparation method thereof. Background technique [0002] New Houttuyfonate (Sodiμm New Houttuyfonate), the chemical name is sodium lauryl acetaldehyde bisulfite, and the active ingredient Houttuyfonate in natural fishy fish is the same series of sodium bisulfite addition thing. The pharmacological effects and curative effects of the two are basically similar, and both are anti-inflammatory and antibacterial drugs. New houttuyfonate sodium has a broad antibacterial spectrum, and can also increase the level of serum properdin, enhance the phagocytosis of 100 cells, and improve the non-specific immunity of the body. It is clinically used to treat respiratory tract infection, pneumonia, bronchitis, urinary tract infection, etc., as well as gynecological pelvic inflammatory disease,...

Claims

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Application Information

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IPC IPC(8): A61K31/255A61K31/185A61P11/00
Inventor 宁宗超侯鹏
Owner 周艳
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