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Preparation method of compound Chinese medicinal polysaccharide and its use

A compound traditional Chinese medicine polysaccharide, compound traditional Chinese medicine technology, applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of few studies on the determination of anti-tumor active ingredients, affecting clinical rational and safe drug use, and toxic and side effects of traditional Chinese medicine, etc. Easy operation, simple preparation method, easy preparation effect

Inactive Publication Date: 2006-08-30
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0003] Most traditional Chinese medicines have toxic and side effects, which affect the rational and safe clinical use of drugs, while traditional Chinese medicine polysaccharides, which have pharmacological properties such as enhancing the body's immune function and anti-tumor, have almost no toxicity
As the common anti-tumor traditional Chinese medicines, Xanthophyllum and Angelica sinensis, most of the research on them only stays in the separation and identification of their components, and there are very few studies on the determination of their anti-tumor active ingredients, and there is no research on the composition of Xanthogyaozi angelica. Polysaccharide Extraction and Content Determination of Compound Traditional Chinese Medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take compound Chinese medicine (Xantaozi and Angelica, mass ratio is 1:3), pulverize; add 1 times volume / weight of 95% ethanol to the obtained medicine powder for ultrasonic extraction and degreasing for 1 hour; evaporate the medicine powder solvent, add 1 times the weight of distilled water, and then ultrasonically Extract for 6 hours, combine the extracts, and filter; depressurize the filtrate to concentrate it to 0.1 times the original volume, add ethanol to adjust the alcohol content of the solution to 80%, and let it stand overnight to obtain a white flocculent precipitate; filter the precipitate, and then use 95% After repeated washing with ethanol, absolute ethanol and diethyl ether, the compound Chinese medicine polysaccharide was obtained by vacuum drying to constant weight. The total sugar content was determined to be 15.023% by using the principle of sulfuric acid-phenol colorimetry.

Embodiment 2

[0019] Get 100g of compound Chinese medicine (Xantaozi and Angelica sinensis, mass ratio is 3: 2), pulverize; Gained medicine powder is added 95% ethanol ultrasonic extraction degreasing 2 hours of volume / weight of gained; Dry medicine powder solvent, add 2 times of weight distilled water, again Ultrasonic extraction for 2 hours, combined extracts, filtered; decompressed filtrate was concentrated to 0.5 times the original volume, added ethanol to adjust the alcohol content of the solution to 80%, left overnight to obtain a white flocculent precipitate; filtered out the precipitate, followed by 95 % ethanol, absolute ethanol, ether, after repeated washing, vacuum drying to constant weight to obtain the compound polysaccharide of traditional Chinese medicine. The total sugar content was determined to be 16.320% by using the principle of sulfuric acid-phenol colorimetry.

Embodiment 3

[0021] Take compound Chinese medicine (Xantaozi and Angelica sinensis, mass ratio is 3:1), pulverize, use 8 times volume / weight of 75% ethanol for ultrasonic extraction and degreasing for 6 hours; evaporate the powder solvent, add 6 times the weight of distilled water, and then ultrasonically extract for 4 hours , combined extracts, and filtered; the decompression filtrate was concentrated to 0.8 times the original volume, added ethanol to adjust the alcohol content of the solution to 80%, and left overnight to obtain a white flocculent precipitate; After repeated washing with water, ethanol and diethyl ether, the compound Chinese medicine polysaccharide was obtained by vacuum drying to constant weight. The total sugar content was determined to be 17.020% by using the principle of sulfuric acid-phenol colorimetry.

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Abstract

A process for preparing the composite Chinese-medicinal polyose used to prepare the antineoplastic medicines includes such steps as pulverizing airpotato yam rhizome and Chinese angelica root, ultrasonic extracting in alcohol, defatting, filtering, volatilizing solvent, adding distilled water, ultrasonic extracting, filtering, vacuum concentrating, adding alcohol, laying aside for depositing, filtering, cyclic washing with alcohol and ether, and vacuum drying.

Description

technical field [0001] The invention relates to a preparation method and application of a compound traditional Chinese medicine polysaccharide, and more specifically relates to a preparation method and an application of a compound traditional Chinese medicine polysaccharide of xanthophyll and angelica. Background technique [0002] Polysaccharides are widely found in animal cell membranes, plant and microbial cell walls, and are a class of natural polymers. They are polymers linked by aldose or ketose through glycosidic bonds, and are one of the four basic substances that constitute life. . Sugars are widely distributed in traditional Chinese medicine, accounting for 80% to 90% of the dry weight of plants, and the activity of many traditional Chinese medicines is closely related to sugar and its derivatives, especially the glycosides combined with sugar and non-sugar substances, many of which have physiological activity. Current studies believe that TCM polysaccharides mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K31/715A61P35/00
Inventor 方岩雄方爱姿陈振业张赛丹陈敏敏张焜
Owner GUANGDONG UNIV OF TECH
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