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Use of aconine in medicine manufacture

A technology of aconitamine and analgesics, which is applied in the field of aconitamine hydrolyzed product of aconitine, can solve the problems of high toxicity, hidden danger, safety and the like of aconitine, so as to improve working efficiency, reduce toxicity and increase The effect of oxygen supply

Inactive Publication Date: 2006-09-27
成都明昌节能环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention aims to solve the problem that aconitine is highly toxic and has potential safety hazards in pharmacy, and provides a hydrolyzed product of aconitine, aconitine, and the use of aconitine in pharmacy

Method used

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  • Use of aconine in medicine manufacture
  • Use of aconine in medicine manufacture
  • Use of aconine in medicine manufacture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0033] Example 2 Acute toxicity test in mice

[0034] A. Test drug

[0035] Aconitine extract (1 gram is equivalent to 60 grams of native medicine), when used by humans, its concentration is formulated as 20mg / 100ml, 0.75ml / time, 3-6 times / day, calculated as 0.000015g / Kg per kilogram of body weight. day. The maximum concentration of the prepared aconitamine extract is 0.3g / ml, and it is used for gavage of mice during the experiment.

[0036] B. Test animals

[0037] Kunming mice were provided by the Experimental Animal Center of Sichuan Academy of Sciences and rationed with full-price pellets. After weighing, they were fed in boxes according to sex, 5 per box. The laboratory temperature is controlled at 18-22°C, and the humidity is controlled at 50-60%.

[0038] C. Test method

[0039] The method of administration is gastrointestinal administration, and a preliminary test is carried out before the formal experiment. The lethal dose range of aconitamine caused by 0% to 100% mortali...

Embodiment 3

[0045] Example 3 Hot plate analgesia test

[0046] Twenty-one female mice were selected and divided into 3 groups, 7 in each group. Different medicinal solutions were applied to the soles of the mice. The test group was smeared with aconitamine, the control group was smeared with morphine, and the blank group was smeared with saline. Heat the three iron plates to 50℃, let the three groups of mice move on the hot plate respectively, and measure the pain threshold (that is, the time to start licking the limbs and twisting the body) and the number of writhing times of the mice. The results are as follows :

[0047] Average pain threshold Number of twists

[0048] Test group 28 seconds 18 times

[0049] Control group 23 seconds 26 times

[0050] Blank group 12 seconds 34 times

[0051] It can be seen from the above results that not only there is a very significant difference between the test group and the blank group, P<0.005, but also between the test group and the control...

Embodiment 4

[0052] Example 4 Clinical experiment

[0053] Use aconitamine analgesic spray to spray the pain of 100 patients with gout; use aconitine analgesic ointment and / or cream to massage the pain of 500 patients with arthralgia and trigeminal neuralgia; use aconitamine Analgesic sprays or analgesic creams (creams) were used to treat 400 patients with low back and leg pain.

[0054] Results In the above cases, the pain relieved or disappeared within 3 minutes of medication.

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PUM

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Abstract

The present invention discloses the pharmaceutical use of aconine. Aconine has obvious effects of relieving pain, raising blood pressure, stimulating heart, strengthening cardiac contractility, diminishing inflammation, etc. and is used in preparing analgesic, anesthetic, drug addiction eliminating medicine and fatigue eliminating medicine. Aconine has the same pharmaceutical activity of aconitine but 2000 times lower toxicity and is pharmaceutically safe and reliable. Various aconine preparations has high curative effect, high safety, no dependence and excellent application foreground.

Description

Technical field [0001] The invention relates to aconitine, a hydrolysate of aconitine, in particular to the use of aconitine in pharmacy. Background technique [0002] Aconitine raw products contain a variety of diester alkaloids, such as Aconitine, Mesaconitine, Hypaconitine, etc. The active ingredient is aconitine. Various pharmacological tests have shown that aconitine alkaloids are effective in analgesia, transient hypotension, transient increase in blood pressure, slowing heart rate, strengthening heart, increasing myocardial contractility, anti-inflammatory, improving immunity, local anesthesia and anti-cold All aspects have obvious effects. It is also known that dl-Demethylcoclaurine, Higenamine, a trace amount of active ingredient isolated from Japanese Aconitum, also has a cardiotonic effect, and this alkali has a strong effect. Dilute it to 10 -9 Cardiotonic activity is still displayed when the time, the structural formula of the compound hydrochloride is as follows: ...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61K31/485A61K9/00A61P25/04A61P23/00A61P43/00
Inventor 张树铭
Owner 成都明昌节能环保科技有限公司
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