Tape preparation

A preparation and rubber adhesive technology, applied in bandages, anti-inflammatory agents, adhesives, etc., can solve problems such as complex preparations

Inactive Publication Date: 2006-10-04
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These reports all use capsaicin as auxiliary reagents to obtain warm feeling, promote blood circulation etc., on the contrary only have very few reports about above-mentioned belt preparation containing capsaicin as main reagent, these very few reports aim at Analgesic or antipruritic effects based on the physiological activity of capsaicin, and the composition of these preparations is quite complex (JP-T-2002-514221)

Method used

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  • Tape preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] High molecular weight polyisobutylene (52 parts, viscosity average molecular weight is 2,100,000, product name: VISTANEX MML-140, produced by Exxon Chemical Co.), medium molecular weight polyisobutylene (28 parts, viscosity average molecular weight is 60,000, product name: HIMOL 6H , produced by NIPPON PETROCHEMICALS CO., LTD.) and alicyclic petroleum resin (20 parts, softening point 100°C, product name: ARKON P-100, produced by Arakawa Chemical Industries, Ltd.) were dissolved in hexane to form a rubber bond agent solution. Capsaicin was added to the solution so that the content of capsaicin in the adhesive layer was 0.025%. The mixture was stirred well and applied on the release liner so that the dried thickness was 80 μm. The mixture dries to form an adhesive layer. Polyester knitted support (basic weight 107g / m 2 , thickness 500 μm) was laminated on the adhesive layer to form the tape preparation of the present invention.

Embodiment 2

[0040] In the same manner as in Example 1, a rubber adhesive solution was prepared, and isopropyl myristate (fatty acid ester) and capsaicin were added to the adhesive layer, and their content in the adhesive layer was 40% and 0.025%, respectively. The mixture was stirred well, and in the same manner as in Example 1, a tape preparation was obtained.

Embodiment 3

[0042] In the same manner as in Example 2 except that the support was changed to a PET film (25 μm in thickness), a tape preparation of the present invention was obtained.

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Abstract

The present invention provides a tape preparation including a support and an adhesive layer directly or indirectly formed on at least one surface of the support, wherein the adhesive layer contains a rubber adhesive containing at least one kind of rubber polymer and capsaicin as an active ingredient. Since the adhesive layer shows extremely fine adhesive property and superior capsaicin releaseability, a rapid pharmacological effect can be afforded with a small capsaicin content.

Description

technical field [0001] The present invention relates to a tape preparation containing capsaicin as an active ingredient for sustained administration of the active ingredient in a living body. Background technique [0002] Continued administration of capsaicin to the living body will lead to the degeneration of the first-order sensory neurons and the degeneration of pain perception to stimulation ("Review Of the Effectiveness ofCapsaicin for Painful Cutaneous Disorders and Neural Dysfunction, Clin JPain14:97-106.1998) of Martin Hautkappe et al. .As an external drug containing capsaicin, which is intended to relieve pain or itching of postherpetic neuralgia, diabetic neuralgia, spontaneous itching, etc., creams and ointments utilizing this effect (Zostrix, Gen Derm Corporation , U.S.A.), (JP-B-3211027, Japan Hospital Pharmacists Association ed. "Hospital Pharmacists Preparation, Forth Edition" 189.1997) have long been familiar with. However, because capsaicin (the irritant com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/165A61P25/04A61P17/04A61P17/06A61P29/00
CPCC09J2205/102A61K9/7061C09J7/0214C08K5/101A61K9/7053A61K9/7007A61K31/00A61P13/02A61P17/04A61P17/06A61P19/02A61P21/00A61P25/04A61P25/06A61P29/00A61P37/08C09J7/383C09J2301/408A61F13/0203A61F2013/00412A61M25/02A61M2025/0266
Inventor 花谷昭德伊藤雅章斋藤纯一
Owner NITTO DENKO CORP
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