A triptolide composite preparation for treating osteoarthritis by joint intracavity injection

A technology of triptolide and triptolide, which is applied in the field of triptolide compound preparations, can solve the problems of low local absorption rate, poor tissue permeability, skin irritation, etc., and achieve reduced dosage, significant therapeutic effect, and reduced Toxic effects
CN1864662AInactive Publication Date: 2006-11-22THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
Publication Date
2006-11-22
Estimated Expiration
Not applicable · inactive patent
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Abstract

The present invention relates to one kind of compound triptolide alcohol preparation for being injected into articular cavity to treat osteoarthritis. It includes triptolide alcohol solution of 1*10<-4> to 5*10<-2> mg / ml concentration and gel liquid mixed in the volume ratio of 1 to 1-9. It has medicine slow releasing effect, and this can prolong the action period of medicine, reduce consumption of triptolide alcohol and lower the toxic side effect of the medicine. It can inhibit the further development of osteoarthritis in early and middle phase, improve the environment inside the joint and promote the regeneration and repair of articular cartilage to reach the aim of cure osteoarthritis.
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Description

Technical field:

[0001] The invention relates to an injection preparation for treating osteoarthritis, in particular to a triptolide compound preparation for intra-articular injection for treating osteoarthritis. technical background:

[0002] Osteoarthritis (Osteoarthritis) is the most common chronic osteoarthritis characterized by joint cartilage degeneration and secondary bone hyperplasia, which can be divided into primary and secondary. Osteoarthritis is the second leading cause of long-term disability after cardiovascular disease in people over the age of 50. Disease surveys show that the prevalence rate of osteoarthritis in my country is about 10%, and the prevalence rate of the elderly over 60 years old is as high as 50%, and its prevalence rate rises linearly with the increase of age; the incidence rate in rural areas is 9.6%, compared to 49% among urban retirees. In recent years, there have been a lot of studies on the drug treatment of osteoarthritis, and new drug...

Claims

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