Plaster

A patch and patch technology, applied in medical science, plant raw materials, bandages, etc., can solve the problems of reduced shape-forming ability, reduced adhesion, reduced strength, etc., to prevent loss and content reduction, keep shape unchanged, Prevents the effects of physical changes

Inactive Publication Date: 2006-11-22
MORIMOTO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, when the adhesive layer is coated on a non-woven fabric, the hydrogel therein has poor stability and thus easily decomposes in contact with water, resul...

Method used

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Examples

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Embodiment 1

[0036] The patch in the first embodiment of the present invention will be described in detail below. The patch in this embodiment is a cataplasm with a cooling effect, and its formula is shown in Table 1. As a comparison, the cataplasm formulations of the prior art are shown in Table 2.

[0037] The patch in this embodiment uses trehalose at a content of 0.5-10.0%, and its drug effect is stable without discoloration. The gel after adding trehalose becomes a microgel with a water content as high as 70-85%, so even if the amount of polyacrylic acid and CMCNa is reduced, good adhesion can be obtained. In addition, the paste used in combination with trehalose has fast spreading speed and low manufacturing cost.

[0038]Manufacturing method: Weigh tartaric acid, purified water, glycerin, kaolin, CMCNa, titanium oxide, sodium polyacrylate, trehalose and mix and stir for 30 minutes, then evenly add Tween-80, synthetic menthol, methyl salicylic acid, Sorbitan sesquioleate and anhyd...

Embodiment 2

[0042] Next, the patch in the second embodiment of the present invention will be described in detail. The patch in this example is a cataplasm with a warming effect, and its formulation is shown in Table 3. As a comparison, the formulations of cataplasms with warming effect in the prior art are shown in Table 4.

[0043] Formula example of cataplasm with warming effect of the present invention

[0044] Prescription examples of cataplasms with warming effect in the prior art

Embodiment 3

[0046] The patch in the third embodiment of the present invention will be described in detail below. The patch in this example is used as a cooling patch, and its formulation is shown in Table 5. As a comparison, the formula of the cooling patch in the prior art is shown in Table 6.

[0047] Manufacturing method: Weigh tartaric acid, purified water, sodium polyacrylate, trehalose, sodium acrylate polymer and glycerin and mix and stir for 30 minutes, then evenly add dipropylene glycol, synthetic menthol, paraben and anhydrous Aluminum hydroxide, then spread evenly at 80g / m 2 On the polyester non-woven fabric, the paste weight is 2500g / m 2 , and then press the polypropylene film, and finally cut it into a size of 50mm×130mm and seal it with an aluminum foil bag to obtain a film with excellent cooling performance.

[0048] Example of patch formulation for cooling of the present invention

[0049] Conventional chip formulation example for cooling

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Abstract

The invention discloses a patch with good stability, easy manufacture, low price and high adhesion. The adhesive layer is added with 0.1-10%, preferably 3-7%, of trehalose as a stabilizer. The adhesive layer is mainly composed of hydrogel formed by polyacrylate and high polystyrene adhesive, and contains anti-inflammatory and analgesic drugs such as menthol, capsicum extract with warming effect, and methyl salicylic acid.

Description

technical field [0001] The present invention relates to a patch that is pasted on a suitable part of a person and used for cooling fever and joint inflammation, moisturizing and refreshing the skin, and being used as a medical aid and medicine. Background technique [0002] In the past, the patches that are attached to the body for cooling generally use hydrogel as the adhesive layer on the olefinic non-woven fabric, and the adhesive layer usually uses 20-40% polyacrylate and other components as the adhesive and Components such as glycerin are used as excipients. These aqueous gels are gelled by retaining water through the bridging reaction of components such as polyacrylates, thereby maintaining adhesiveness. As shown in Patent Document 1, the patch is coated with a synthetic rubber-like adhesive on the fiber layer of the non-woven fabric, so that it can remain intact even in cold weather or soaked in water-soluble polymer materials such as gelatin. Stablize. And as show...

Claims

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Application Information

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IPC IPC(8): A61L15/16A61K36/81A61L15/22A61L15/42
Inventor 横井秀辅盛本修司
Owner MORIMOTO PHARMA CO LTD
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