Slow-release injection contg. platinum compounds and cellulotoxic medicines

A technique for sustained-release injections and compounds, applied in the fields of sustained-release injections and sustained-release implants, sustained-release injections and their preparation, which can solve problems such as difficult operation, poor curative effect, and many complications
CN1868453AInactive Publication Date: 2006-11-29SHANDONG LANJIN PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG LANJIN PHARMA
Publication Date
2006-11-29
Estimated Expiration
Not applicable · inactive patent
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Abstract

A slow-release anticancer injection is composed of the slow-release microballs containing active component and slow-releasing auxiliary and the special solvent containing the suspending aid. Said active component is the combination of Pt compound chosen from dicycloplatinum, etc and the cellulotoxic medicine chosen from doxorubicin, vinorelbine, etc. Said slow-releasing auxiliary is chosen from polylactic acid or its copolymer, monoethyl polyethanediol or its copolymer, EVAc, etc.
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Description

(1) Technical field

[0001] The invention relates to a slow-release injection simultaneously carrying platinum compounds and cytotoxic drugs and a preparation method thereof, belonging to the technical field of medicines. Specifically, the present invention provides a slow-release preparation of anticancer drugs containing platinum compounds and cytotoxic drugs, mainly slow-release injections and slow-release implants. (2) Background technology

[0002] As one of the conventional treatment methods for cancer, chemotherapy drugs have been widely used in the treatment of various malignant tumors, and the effect is relatively obvious. However, its obvious systemic toxicity greatly limits the application of this drug.

[0003] Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conven...

Claims

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