Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method of extracting qinghaosu

A technology of artemisinin and cyclic extraction, which is applied in the direction of organic chemistry, can solve the problems of long time, low extraction rate, and large amount of organic solvents, so as to reduce environmental pollution, reduce the number of recrystallization times, and increase the overall yield Effect

Inactive Publication Date: 2006-11-29
WUHU TALENT NATURAL EXTRACT
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is, use organic solvents such as ethanol and gasoline to extract Artemisia annua, the extraction rate of this method is low, the time is long, and a large amount of organic solvents are required
Another kind is supercritical liquid extraction method, and the extraction rate of this method is high, is divided into extraction process and analytical separation process, as Chinese patent (93166143.1) records, with supercritical carbon dioxide (CO ) as extraction solvent, at extraction pressure 8-32 megapascals (MPa), extraction temperature 30-70°C, analysis temperature 30-75°C, analysis pressure 4-8MPa, extraction time 0.5-5 hours (h) for rough extraction, but the impurities in the obtained crude product For example, the high content of pigments and lipids makes the subsequent recrystallization process complicated, requires multiple recrystallizations, and uses a large amount of organic solvents, which affects the overall yield of artemisinin and is likely to cause serious pollution to the environment.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method of extracting qinghaosu

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The dried Artemisia annua raw material was pulverized, sieved and weighed 2 kg into the extraction kettle 1, and the temperature control of the extraction kettle 1 and the analysis kettles 2 and 3 was started after the materials were loaded. When the extraction temperature reaches 10°C and the temperature of the analysis kettle 2 and 3 reaches 40°C, pressurization is started, and the CO 2 Pressurize the extraction kettle 1 and the desorption kettle 2, 3 at a flow rate of 0.62L / min, start extraction when the extraction kettle 1 reaches 15MPa and the desorption kettle 2, 3 reaches 6MPa, and through the control of the pressure regulating valve 10, 11, Keeping the above parameters constant, after 5 hours of extraction, shut down and discharge to obtain 93g of crude artemisinin, wherein the content of artemisinin is 15.8%. The crude product was then crystallized from aqueous ethanol. The purity is 99.5%. The yield of the whole process is 92.6%.

Embodiment 2

[0018] Operated in the same manner as Example 1, throwing 2 kg of Artemisia annua, extracting for 5 hours at an extraction pressure of 15 MPa, a separation pressure of 6 MPa, an extraction temperature of 15 °C, a separation temperature of 35 °C, and a CO2 flow rate of 0.62 L / min, to obtain 97 g of crude artemisinin, of which Artemisinin content is 15.4%. The artemisinin fine product was obtained by recrystallization with aqueous methanol, with a purity of 99.6% and an extraction rate of 93.2% in the whole process.

Embodiment 3

[0020] Operated in the same manner as in Example 1, throwing 2 kg of Artemisia annua, extracting for 5 hours at an extraction pressure of 25 MPa, a separation pressure of 6 MPa, an extraction temperature of 5 ° C, a separation temperature of 45 ° C, and a CO2 flow rate of 0.62 L / min, to obtain 93 g of crude artemisinin, of which Artemisinin content is 16.1%. The refined artemisinin was obtained by recrystallization with ethanol aqueous solution, the purity was 99.8%, and the extraction rate of the whole process was 94.3%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A process for extracting artemisinin features that the liquid-state CO2 is used as solvent to cyclically extracting artemisinin at 5-28 deg.C, and the obtained crude artemisinin has high purity.

Description

Technical field: [0001] The invention belongs to the technology of preparing sesquiterpene lactone compound by using natural plants, in particular to the method of extracting artemisinin from Artemisia annua. Background technique: [0002] Artemisinin is a sesquiterpene lactone compound containing peroxy groups extracted from Artemisia annua L. Artemisinin has been proved by a large number of pharmacological clinics to be quick-acting and low-toxic in the treatment of falciparum malaria, cerebral malaria and chloroquine-resistant strains of malaria. Artemisinin can be used as a raw material to prepare its derivatives artemether, artether, sodium artesunate, reduced artemisinin, etc., which have equal or better antimalarial effects. [0003] Researchers have conducted a lot of research on the process of isolating artemisinin from Artemisia annua. There are mainly two main extraction methods: one is the organic solvent atmospheric pressure extraction method. That is to use ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D493/18
Inventor 王宪达包勇霍跃胡云翔江飚陈树华马成盘
Owner WUHU TALENT NATURAL EXTRACT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com