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Biological type artificial blood vessel and method for preparing the same

A kind of artificial blood vessel, bio-based technology, applied in the field of artificial blood vessels, can solve the problems that vascular cells are difficult to grow, proliferate and migrate, difficult to reach, and cannot effectively remove antigens, etc., to ensure long-term patency, good blood compatibility, Anti-coagulant effect

Inactive Publication Date: 2007-01-31
SUMMIT GD BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the traditional treatment method, decellularization is used as an effective means to remove antigens, but according to the research results of molecular biology and molecular immunology, it is known that antigens do not come from cells, but from active groups at certain specific positions in proteins and polysaccharides. Groups, or specific conformations, these specific groups or conformations are collectively referred to as antigenic determinants, only by blocking the active group as the antigenic determinant and changing the specific conformation as the antigenic determinant, can the antigen be effectively removed. ineffective removal of antigen
Therefore, in the traditional method of treating animal blood vessels, due to the residual toxicity of glutaraldehyde and the chronic weak immune rejection caused by incomplete removal of antigens, it is difficult for the endothelial cells and other vascular cells of the host blood vessels to grow and proliferate in artificial blood vessels. and migration, it is difficult to achieve the desired effect

Method used

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  • Biological type artificial blood vessel and method for preparing the same
  • Biological type artificial blood vessel and method for preparing the same
  • Biological type artificial blood vessel and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: as attached figure 1 and 2 As shown, the bioartificial blood vessel is composed of a base material 1 formed from animal blood vessels that have been cross-linked and fixed by epoxy oxides and treated with antigen removal, and an anticoagulant component bonded on the inner surface of the base material 1. Surface layer 2 composition. The base material 1 is a straight tubular body, and the anticoagulant component in the surface layer 2 is heparin; the surface layer 2 also contains 16 lysine (K16), glycine (G), arginine (R), aspartic acid (D), serine (S), proline (P) and cysteine ​​(C) condensation polypeptide.

[0030] The preparation method of biological artificial blood vessel is based on natural animal blood vessel, comprising the following steps:

[0031] (1) Pretreatment: use broad-spectrum sterilizers such as brogeramine, chlorhexidine, etc. for initial sterilization, and then trim and remove excess tissue;

[0032] (2), degreasing: use organic solv...

Embodiment 2

[0037] Embodiment 2: as attached image 3 As shown, the substrate 1 is a U tubular body, and diisocyanate is used to immobilize protein molecules. Other technical features are the same as in Example 1, and will not be repeated here.

Embodiment 3

[0038] Embodiment 3: as attached Figure 4 As shown, the substrate 1 is a C tubular body, and diamide diamide is used to immobilize protein molecules. Other technical features are the same as those in Embodiment 1, and will not be repeated here.

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Abstract

A biologic artificial blood vessel is composed of a basic material prepared from animal's blood vessel through cross-linking by fixing agent and removing antigen, and a surface layer bonded on the inner surface of said basic material and containing anticoagulation component. Its advantages are high biologic compatibility, safety and blood compatibility, and no blood coagulation. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an artificial blood vessel, which is a device used to replace damaged blood vessels or serve as a bridge for blood vessels, and belongs to the medical equipment implanted into the human body. Background technique [0002] Vascular disease has become one of the important diseases that threaten human health and life. The main treatment for vascular diseases is to replace the diseased blood vessels with artificial blood vessels or to bypass the two sides of the diseased blood vessels. At present, artificial blood vessels in clinical application are mainly polyester braided tubes and expanded polytetrafluoroethylene tubes, both of which are made of synthetic materials. Although pseudointima can be formed to maintain its long-term patency, they always exist in the body as permanent foreign bodies. It will always cause more or less chronic weak rejection, which is not good for the body, and its anticoagulant property is not good. On...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06
CPCA61L2430/36A61L27/3683A61L27/227A61F2/06A61L27/3625A61F2/062A61L33/128
Inventor 徐国风
Owner SUMMIT GD BIOTECH
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