Piroxicam medicinal preparation and preparing method thereof

A technology for piroxicam and pharmaceutical preparations, applied in the field of piroxicam pharmaceutical preparations and preparation thereof, can solve the problems of insufficient uniformity of administration, slow action, tenderness of patients, etc., achieves good antipyretic and analgesic effect, good wound protection, and use handy effect

Inactive Publication Date: 2007-02-28
湖北南洋药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inconvenient use of injections is self-evident; capsules and tablets must be taken orally, digested and absorbed by the digestive tract, and detoxified by the liver after a series of functional effects and then enter the blood circulation to exert their antipyretic and analgesic effects. The dosage is 10mg~20mg once for an adult, and it has the common disadvantages of oral preparations, such as dose limitation in severe cases, slow action, stimulation and damage to internal organs, contraindications to internal organ functions, etc., and it will be accompanied by some adverse reactions, such as A small number of patients may experience nausea, vomiting, stomach

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: 200 grams of povidone (PVPK30) are mixed with 340 grams of propylene glycol, then add 200 grams of glycerin, then join in the ethanol (50 grams: 3500 milliliters) solution that is dissolved with piroxicam, then add 10 grams of Laurocaprazine, adjust the total amount with ethanol to be 5000 milliliters, fully stir, filter, obtain filtrate, pack into pressure-resistant container and seal, every bottle of 50 milliliters, fill into CFC-12, every bottle of 15 grams, bath inspection, Pack and serve.

Embodiment 2

[0027] Embodiment 2: 220 grams of povidone (PVPK30) are mixed with 320 grams of propylene glycol, then add 250 grams of glycerin, then join in the ethanol (50 grams: 3500 milliliters) solution that is dissolved with piroxicam, then add 10 grams of Turpentine, adjust the total amount with ethanol to be 5000 milliliters, fully stir, filter, obtain the filtrate, pack into pressure-resistant containers and seal, every bottle of 50 milliliters, fill with dimethyl ether, every bottle of 22 grams, bath inspection, packaging, namely have to.

Embodiment 3

[0028] Example 3: Mix 250 grams of polyethylene glycol with 290 grams of propylene glycol, then add 200 grams of glycerin, then add it to the solution of ethanol (50 grams: 3500 milliliters) in which piroxicam is dissolved, and then add 5 grams of Sethone , adjust the total amount to 5000 milliliters with ethanol, fully stir, filter to obtain the filtrate, pack it into a pressure-resistant container and seal it, 50 milliliters per bottle, fill it with CFC-12, 15 grams per bottle, bath test, pack, and obtain .

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PUM

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Abstract

The invention relates to a pharmaceutical preparation of piroxicam and process for preparation, wherein the pharmaceutical preparation comprises 0.5-10 weight parts of piroxicam as active composition, 5-95 weight parts of medicinal adjuvant, and 5-90 weight parts of casting agent. The preparation has the advantages of easiness in use, higher safety and reliability, and better analgesic and analgesic effects.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical preparation of piroxicam and a preparation method thereof. Background technique [0002] Piroxicam is an antipyretic and analgesic non-steroidal anti-inflammatory drug. At present, there are six dosage forms of piroxicam preparations on the market including ointment, tablet, capsule, injection, gel and liniment. The inconvenient use of injections is self-evident; capsules and tablets must be taken orally, digested and absorbed by the digestive tract, and detoxified by the liver after a series of functional effects and then enter the blood circulation to exert their antipyretic and analgesic effects. The dosage is 10mg~20mg once for an adult, and it has the common disadvantages of oral preparations, such as dose limitation in severe cases, slow action, stimulation and damage to internal organs, contraindications to internal organ ...

Claims

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Application Information

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IPC IPC(8): A61K31/5415A61K9/12A61P29/00
Inventor 杨建科
Owner 湖北南洋药业有限公司
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