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Vitexin injection and oral administration preparation thereof

An oral preparation, the technology of vitexin, applied in the field of medicine, can solve the problems of low purity, mixed ingredients, difficult quality control, etc., and achieve the effect of controllable quality and high application value

Inactive Publication Date: 2007-02-28
合肥七星医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hawthorn leaves are rich in flavonoids, such as vitexin, vitexin rhamnoside, vitexin glucoside, etc., which can inhibit platelet aggregation, expand coronary arteries, improve myocardial blood supply, reduce myocardial oxygen consumption, It has an obvious protective effect on ischemic heart disease. It is mainly used clinically for coronary heart disease, angina pectoris, hyperlipidemia, and cerebral arterial insufficiency. Seriously hinder clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] Example 1: (small water needle)

[0007] Component:

[0008] Vitexin 3g

[0009] Propylene glycol 150g

[0010] 0.1mol / L NaOH 100ml

[0011] Add water for injection to 1000ml

[0012] Preparation Process:

[0013] Take vitexin and add 0.1mol / L NaOH and propylene glycol to dissolve it, add water for injection to the full amount, add needles to decolorize with activated carbon, filter, fill, and sterilize to obtain. The vitexin content should be 90% to 110% of the labeled amount.

Embodiment 2

[0014] Embodiment 2: (freeze-dried powder injection)

[0015] Component:

[0016] Vitexin 10g

[0017] Mannose 100g

[0018] 0.1mol / L NaOH 200ml

[0019] Made up to 1000 pieces

[0020] Preparation Process:

[0021] Take vitexin and add 0.1mol / L NaOH and mannitol to dissolve it, then add water for injection to the full amount, add needles to decolorize with activated carbon, filter, fill, and freeze-dry to obtain. The vitexin content should be 90% to 110% of the labeled amount.

Embodiment 3

[0022] Embodiment 3: (sodium chloride infusion 100ml / bottle)

[0023] Component:

[0024] Vitexin 0.2g

[0025] 0.1mol / L NaOH 100ml

[0026] Sodium chloride 9g

[0027] Add water for injection to 1000ml

[0028] Preparation Process:

[0029] Take vitexin and add 0.1molmol / L NaOH to dissolve it, then add sodium chloride and water for injection to the full amount, add needles to decolorize with activated carbon, filter, subpackage, and sterilize to obtain the product. The vitexin content should be 90% to 110% of the labeled amount.

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PUM

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Abstract

The invention relates to a Vitexin injection or oral administration preparation for treating cardiovascular diseases and process for preparation, wherein each 1000ml of the Vitexin injection comprises Vitexin 0.1-100g, each 1000 dosage units of the oral administration preparation comprises Vitexin 0.1-100g, and medicinal supplementary materials comprises diluent, flow aid, auxiliary solvent, excipient and osmoregulation agent.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a medicament for treating cardiovascular diseases, in particular to a vitexin injection (small water injection, freeze-dried powder injection, glucose injection and sodium chloride injection) and an oral preparation ( Tablets, capsules, drop pills, soft capsules, oral liquid, granules, aerosol), can be used for arteriovenous injection or oral administration. The vitexin injection contains 0.1-100g of vitexin per 1000ml, and the oral preparation contains 0.1-100g of vitexin per 1000 preparation units. And the application of the vitexin preparation obtained by the method of the invention in the field of pharmacy, especially the application in the preparation of drugs for preventing and treating cardiovascular diseases. Background technique [0002] Hawthorn is one of the commonly used medicines in traditional Chinese medicine and has a long history of clinical application. Hawthorn...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/85A61P9/10A61P3/06
Inventor 邵旭何万龙
Owner 合肥七星医药科技有限公司
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