Lyophilized powder injection of baikal skullcap root extract and preparation method thereof
A technology of Scutellaria baicalensis extract and freeze-dried powder injection, which is applied in the field of scutellaria baicalensis extract freeze-dried powder injection and its preparation, can solve the problem that the scutellaria baicalensis extract cannot be made into injections, and achieve the effects of definite curative effect, stable quality and high purity
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Embodiment 1
[0043] The water for injection is heated and deoxygenated. Dissolve 220g of meglumine in 2000ml of deoxygenated water for injection to make a meglumine solution. Take 100g of nicotinamide and 50g of ascorbic acid to dissolve in 4000ml of deoxygenated water for injection and add baicalein 80g is made into a suspension, and then 2000ml of meglumine solution is slowly added to the above 4000ml suspension under stirring, and the stirring is continued to dissolve all the baicalein, add 6g of filler mannitol, and then add 0.3% of the total weight of the liquid Use activated carbon for needles, stir for 25 minutes at room temperature, filter with No. 4 sand core rod, and filter with 0.22μф300mm aseptic membrane under pressure. After the predicted content and pyrogen are qualified, aseptically dispensed into 10ml vials, each bottle Pack about 3ml, freeze-dry, and make 1700 bottles of finished products (loss during filtration and packing), each bottle contains 33mg of baicalein (active c...
Embodiment 2
[0045] Ultrasonic deoxygenation of water for injection, dissolve 300g of arginine in 1000ml of peroxygen-free water for injection to make an arginine solution, take 80g of nicotinamide and 40g of sodium ascorbate and dissolve it in 2000ml of peroxygen-free water for injection and add baicalein 40g and 40g of baicalin are made into a suspension, and then 1000ml of arginine solution is slowly added to the above 2000ml suspension under stirring, and stirring is continued to dissolve all the baicalin and baicalin, and then add 0.3% of the total weight of the liquid Use activated carbon for needles, stir for 25 minutes at room temperature, filter with No. 4 sand core rod, and filter with 0.22μф300mm aseptic membrane under pressure. After the predicted content and pyrogen are qualified, aseptically dispensed into 10ml vials, each bottle Pack about 3ml, freeze-dry, and make 840 bottles of finished products (loss during filtration and packing), each bottle contains 33mg of baicalein and...
Embodiment 3
[0047] The water for injection is heated and deoxygenated. Dissolve 110g of meglumine in 1000ml of deoxygenated water for injection to make a meglumine solution. Take 80g of acetamide and 40g of sodium bisulfite to dissolve in 2000ml of water for injection that removes peroxygen. Add 80g of baicalin to make a suspension, then slowly add 1000ml of meglumine solution to the above 2000ml suspension under stirring, continue to stir to dissolve all the baicalin, and then add 0.3% of the total liquid weight of activated carbon for needle , Stir at room temperature for 25 minutes, filter with No. 4 sand core rod, pressurized filtration with 0.22μф300mm sterile membrane, after the predicted content and pyrogen are qualified, aseptically dispensed into 10ml vials, each bottle is about 3ml , Freeze-dried to make 850 bottles of finished products (loss during filtration and packaging), each bottle specification contains 66mg of baicalin (active carbon has adsorption of baicalein).
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