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Microsphere of dried tangerine peel oil and method for preparing same

A technology of tangerine peel and oil microcapsules, which is applied in the field of tangerine peel oil microcapsules and its preparation, can solve problems such as difficulty in ensuring the stability of volatile oil, loss of volatile oil in volatilization, cumbersome methods, etc., and achieve good dispersibility, good encapsulation rate and stable process Effect

Inactive Publication Date: 2007-05-23
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation process of traditional solid preparations such as tablets, granules, capsules and other dosage forms, the volatile oil is often dissolved in a small amount of ethanol and other solvents to dilute, and then sprayed into the dry granules. There are 38 kinds of volatile oils in the Pharmacopoeia of the 2005 edition. Finally, it is produced according to the above production process, but this production process is very easy to volatilize and lose the volatile oil, and it is difficult to ensure the stability of the volatile oil during storage and application.
In recent years, there have been many studies on the preparation of volatile oil inclusion compounds using β-cyclodextrin, but this method is cumbersome and the drug loading is low.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 18g of gum arabic powder, dissolve it in water and make it into 300ml of 6% (w / v) concentration, add 3.6g of glycerin, 36g of tangerine peel oil, 1.8g of Tween, stir and emulsify with a tissue homogenizer, then add micronized silica gel 1.8g g, under stirring, the air inlet temperature is 145°C, the outlet air temperature is 85°C, and the spray pressure is 25m 2 / h, spray drying under the process conditions of feeding rate 20ml / min, to obtain final product. The measured drug loading was 28.15%.

Embodiment 2

[0021] Sprinkle an appropriate amount of sodium alginate into a container with 150ml of water and swell overnight to form a 5% (w / v) solution; then take 7.5g of gum arabic powder and dissolve it in water to form a 5% (w / v) solution The concentration is 150ml, and mixed with the above-mentioned sodium alginate solution evenly; add 0.9g of glycerin, 14.5g of tangerine peel oil, and 0.5g of Span to the mixed solution. According to the inlet air temperature of 145°C, the outlet air temperature of 85°C, and the spray pressure of 38m 2 / h, spray drying under the process conditions of feeding rate 20ml / min, to obtain final product. The measured drug loading was 25.92%.

Embodiment 3

[0023] Take 15g of methyl cellulose, dissolve it in water and make it 300ml at a concentration of 5% (w / v), add 1.5g of polyethylene glycol, 3g of tangerine peel oil, and 0.4g of Span into the mixture, stir and emulsify with a tissue homogenizer Finally, add 0.15g of talc powder, stir, according to the air inlet temperature of 155°C, the outlet air temperature of 90°C, and the spray pressure of 38m 2 / h, spray drying under the process conditions of feeding rate 10ml / min, to obtain final product. The calculated drug loading was 27.82%.

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PUM

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Abstract

The invention relates to a method for preparing tangerine peel oil capsule, wherein it comprises capsule material, strengthener, tangerine peel oil, emulsifier, and anti-adhesive agent at 0.5-1:0.05-0.1:0.2-1.2:0.025-0.05:0.01-0.05; atomizes and dries, to obtain the capsule at 7-30 mum. And the inventive capsule can reduce volatilization and improve stability. And it solidifies tangerine peel oil, to support storage and transmission.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a tangerine peel oil microcapsule and a preparation method thereof. Background technique [0002] Volatile oil is a general term for a mixture of various components that can be distilled with water vapor and immiscible with water in plants. Volatile oils are mainly monoterpenes, sesquiterpenes and their oxygenates, which are sensitive to the influence of air, sunlight and temperature, and are easy to decompose and deteriorate. Volatile oil is usually an oily liquid with a special and strong smell, which can be evaporated at room temperature. Chinese herbal medicines contain a large amount of volatile oil and play an important pharmacological role in their formulations. Therefore, how to reduce the loss of volatile oil and maintain its stability in the production of preparations is a concern in the production of traditional Chinese medicine prepa...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/50
Inventor 冯怡徐德生
Owner SHANGHAI UNIV OF T C M
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