Preparation of submicron solid particle suspensions by sonication of multiphase systems

a multi-phase system and solid particle technology, applied in the direction of microcapsules, macromolecular non-active ingredients, chemical/physical processes, etc., can solve the problems of spontaneous formation of microencapsulated products, irritation at the site of delivery, and unstable emulsions
US20050037083A1Inactive Publication Date: 2005-02-17BAXTER INT INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BAXTER INT INC
Publication Date
2005-02-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a method for preparing submicron-sized particles. The method includes the steps of: (1) providing a multiphase system having an organic phase and an aqueous phase, the organic phase having a pharmaceutically effective compound therein; and (2) sonicating the system to evaporate a portion of the organic phase to cause precipitation of the compound in the aqueous phase and having an average effective particle size of less than about 2 m.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] Not Applicable. FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] Not Applicable. TECHNICAL FIELD

[0003] The present invention provides a multistep process for generating submicron-sized particles of water insoluble organic compounds and more particularly a process for preparing submicron-sized particles of a pharmaceutically effective compound by sonicating a multiphase liquid. BACKGROUND OF THE INVENTION

[0004] Background Art

[0005] The ability to deliver pharmaceutical medications in a water-soluble formulation is a critical concern in therapeutic drug development. The fact that poorly soluble drugs can pose difficulties in this area has resulted in the need for new technologies that can address this obstacle. One solution to this problem is the production of extremely small particles of the insoluble drug candidate and the creation of a microparticulate suspension. In this way, drugs that were previously unable to be formulated in ...

Claims

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