Reactive hydrophilic oligomers

a technology of reactive hydrophilic oligomers and crosslinkable oligomers, which is applied in the direction of bandages, dermatological disorders, drug compositions, etc., can solve the problems of insufficient absorption and cohesive strength, and achieve the effects of high performance materials, minimal shrinkage, and purity of materials

Inactive Publication Date: 2005-03-31
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The composition of the present invention minimizes shrinkage due to solvent evaporation and/or monomer polymerization. The low shrinkage compositions of this invention are particularly useful in dental, molding applications or in any applications where accurate molding and/or registration is required. The present invention provides a new class of reactive oligomers that may be formulated as 100% solids, melt processed, cured by actinic radiation means and that exhibit properties that meet or exceed those of solvent-borne or syrup polymers. The present invention provides compositions that exhibit less than 2% shrinkage, and preferably less than 1%.
Further, the purity of the materials and clean environment for proces...

Problems solved by technology

Though there are known hydrophilic gel materials useful in medical applications such as ...

Method used

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  • Reactive hydrophilic oligomers
  • Reactive hydrophilic oligomers
  • Reactive hydrophilic oligomers

Examples

Experimental program
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example 1

A hydrophilic copolymer with photoinitiator pendant groups was synthesized by charging an amber glass bottle with 99.0 g of MPEG, 1.0 g of DAROCUR ZLI-3331, 0.1 g of α-methyl styrene, 0.4 g of VAZO 52 and 100 g of ethyl acetate. The contents of the bottle were purged with N2 for 20 minutes and the bottle was capped, using poly(tetrafluoroethylene) thread tape (available from 3M Co., St. Paul, Minn.) between the cap and the threads of the bottle. The bottle was placed in a Model LLF LAUNDER-O-METER (available from Atlas Electric Devices Co., Chicago, Ill.), with the water bath temperature set at 60° C., for 16 hours. The resulting polymer had a Mn of 36,900 as determined by GPC.

example 2

A hydrophilic copolymer with photoinitiator pendant groups was synthesized by charging an amber glass bottle with 65.0 g of MPEG, 35.0 g of HEMA, 1.0 g of DAROCURE ZLI-3331, 4.0 g of α-methylstyrene, 0.4 g of AIBN and 90 g of ethyl acetate. The contents of the bottle were purged with nitrogen gas for 20 minutes and the bottle was capped, using poly(tetrafluoroethylene) thread tape. The bottle was placed in a water bath shaker at 65° C. for 24 hours. The resulting polymer had a Mn of 15,700 as determined by GPC.

example 3-7

A series of hydrophilic copolymers were synthesized by charging 5 amber glass bottles with different weight proportions of hydrophilic monomers and a-methyl styrene as shown in Table 1. Sufficient ethyl acetate was added to each bottle so that the total monomer concentration was 50 weight percent. VAZO 52 (0.4 g) was added to each bottle. The contents of each bottle was purged with nitrogen gas for 20 minutes and the bottle was capped, using poly(tetrafluoroethylene) thread tape. Each bottle was placed in a Model LLF LAUNDER-O-METER, with the water bath temperature set at 60° C., for 16 hours. Compositions and Mn values for Examples 3-7 are shown in Table 1.

TABLE 1Examples 3-7MPEG-Alpha-ExampleMPEG(g)HEMA(g)DMACM(g)NVA(g)1000(g)methylstyrene(g)Mn393.74.91.043,000498.51.00.134,900564.14.929.61.037,100664.14.929.61.023,80071.098.50.113,200

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Abstract

Hydrophilic compositions are described, which are prepared from a first oligomer containing pendent polymerizable groups and pendent hydrophilic groups, crosslinked with a co-reactive second component oligomer possessing polymerizable groups. The compositions may be used as in preparation of hydrophilic gel coatings or layers for medical devices.

Description

TECHNICAL FIELD OF THE INVENTION This invention relates to novel hydrophilic, crosslinkable oligomer compositions and articles prepared therefrom. The compositions can be useful in preparing gel materials and medical articles incorporating such materials, particularly medical articles useful as wound dressings. BACKGROUND OF THE INVENTION Historically, exudate from a wound has been treated by absorbing it using a dressing containing an absorbent material. Such dressings have contained a padded absorbent material attached to an adhesive tape backing. The padded absorbent material is applied to the wound to absorb the wound exudate. A difficulty with this type of dressing is that the scab typically forms in and as part of the pad as the wound heals. Thus, when the dressing is removed, the scab is removed. This problem has been addressed by providing a porous film between the absorbent material and the wound to reduce the likelihood that a scab formed will become attached to the abso...

Claims

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Application Information

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IPC IPC(8): A61L15/22C08F265/04C08F283/06C08F291/00C08F293/00C08G65/329C08L51/00C08L51/08C08L71/02C09D151/00C09D151/08
CPCA61L15/22C08F265/04C08F283/06C08F291/00C08F293/005C08G65/329C09D151/08C08L51/006C08L51/08C08L71/02C09D151/003C09D151/006C08L51/003C08L2666/02A61P17/02
Inventor LEWANDOWSKI, KEVIN M.FANSLER, DUANE D.WENDLAND, MICHAEL S.HEILMANN, STEVEN M.GADDAM, BABU N.
Owner 3M INNOVATIVE PROPERTIES CO
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