Implantable device for promoting repair of a body lumen

a technology of implantable devices and lumens, which is applied in the field of implantable medical devices, can solve the problems of exacerbated injury, stenosis of atherosclerotic vessels, and damaged arterial surfaces within the vascular system are highly susceptible to thrombosis, so as to promote neointimal proliferation

US20050149170A1Inactive Publication Date: 2005-07-07TASSEL ROBERT A VAN +2
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
Publication Date
2005-07-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and / or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.
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Description

RELATED APPLICATIONS

[0001] This application is a Continuation-In-Part application of U.S. patent application Ser. No. 09 / 139,084, filed Aug. 25, 1998, which is incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] This invention relates generally to an implantable medical device; and more particularly to an implantable stent.

[0004] 2. Discussion of the Prior Art

[0005] Damage to the endothelial and medial layers of a blood vessel, such as often occurs in the course of balloon angioplasty and stent procedures, has been found to stimulate neointimal proliferation, leading to restenosis of atherosclerotic vessels.

[0006] The normal endothelium, which lines blood vessels, is uniquely and completely compatible with blood. Endothelial cells initiate metabolic processes, like the secretion of prostacylin and endothelium-derived relaxing factor (EDRF), which actively discourage platelet deposition and thrombus formation in ves...

Examples

example 1

Temperature vs. Variable Flow Rates

[0101] The concept of flow measurement by the temperature sensitive stent is based upon the principle that a liquid (e.g. blood) flowing through a stent is a cooling medium and that the amount of cooling of a stent that has been heated above body temperature is directly proportional to the flow rate of the liquid through the stent. This is expressed by Equation I above. To validate the use of the heated stent as a measure of flow rate, experimental data was obtained through the bench testing as follows.

[0102] A GR2 type configuration stent was created using 38 AWG Nichrome resistance wire. 30 AWG Type J thermocouples were attached to the stent in three locations described as distal (furthest away from stent heating leads), mid and proximal. The stent was deployed in a simulated blood vessel made of silicone and submerged in a 37° C. distilled water bath. The water bath temperature was held constant during the testing. While a constant voltage of...