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Method of inhibiting alveolar bone resorption and periodontal membrane loss and composition for internal use to be used therein

Inactive Publication Date: 2007-05-10
SUNSTAR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] An object of the present invention is to provide a method, oral composition, and prevention or treatment agent for inhibiting alveolar bone resorption and periodontal membrane loss or inhibiting gingival recession in persons having a tendency for decreased bone density and postmenopausal women, while having a high degree of safety even when the composition or agent is taken for extended periods of time.

Problems solved by technology

Decreased bone density is caused by aging, nutrition / diet problems such as shortage of calcium intake, lack of exercise, medicines such as adrenal corticosteroids, etc.
In particular, women tend to suffer a rapid decrease of bone mass because of decreased estrogen secretion due to menopause.
However, since bisphosphonate has strong side effects, it is not suitable for periodontal disease treatment, which requires long-term medication.
Because inflamed parts and affected tissues are physically removed in the process of treatment, the treated area tends to suffer gingival recession.
Like ordinary calcium supplements, these are in oral tablet, capsule, and powder forms and are not intended for the prevention of periodontal disease.
However, the above periodontal disease prevention is based on the antibacterial properties of soy isoflavones, and there has been no reported case of inhibited periodontal membrane loss.

Method used

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  • Method of inhibiting alveolar bone resorption and periodontal membrane loss and composition for internal use to be used therein
  • Method of inhibiting alveolar bone resorption and periodontal membrane loss and composition for internal use to be used therein

Examples

Experimental program
Comparison scheme
Effect test

example 1

Granule (Ingestion: 4 g per Day)

[0069] Granules were produced by a standard method, using the following components:

ComponentAmount (%)Whey calcium50.00(calcium content: 26%)Soy isoflavone extract1.00(aglycon content: 30%)(genistein:daidzein = 1.5:1)Oil-soluble licorice extract1.00Vitamin D3 (vitamin D3 content: 0.25%)0.05Xylitol40.00PalatinitBalanceAspartame0.10Gum arabic1.00Flavor2.50Total100.00

example 2

Intraoral Solution Tablet (Ingestion: 4 g per Day)

[0070] Intraoral solution tablets were produced by a standard method, using the following components:

ComponentAmount (%)Oyster shell calcium35.00(calcium content: 39%)Soy isoflavone extract0.5(aglycon content: 70%)(genistein:daidzein = 1.3:1)PalatinitBalanceMaltitol30.00Vitamin D3 (vitamin D3 content: 0.25%)0.05Polydextrose5.00Sucrose fatty acid ester4.00Cocoa powder5.00Sucralose1.00Flavor2.50Total100.00

example 3

Intraoral Solution Tablet (Ingestion: 4 g per Day)

[0071] Intraoral solution tablets were produced by a standard method, using the following components:

ComponentAmount (%)Calcium tertiary phosphate35.00(calcium content: 39.1%)Soy isoflavone extract1.50(aglycon content: 33%)(genistein:daidzein = 1.3:1)Vitamin K0.01Vitamin D3 preparation0.1(vitamin D3 content: 0.25%)Xylitol31.00PalatinitBalanceCitric acid0.50Gum Arabic1.20Magnesium stearate1.00Flavor3.00Total100.00

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Abstract

Alveolar bone resorption, periodontal membrane loss, and gingival recession can be inhibited by administering 500 mg to 2000 mg per day of calcium, 10 mg to 40 mg per day of soy isoflavone aglycone, and vitamin D3 to persons having a tendency for decreased bone density, postmeopausal women, and periodontal disease patients in a maintenance phase; and even an extended period of administration provides a high degree of safety.

Description

TECHNICAL FIELD [0001] The present invention relates to a method for inhibiting alveolar bone resorption and periodontal membrane loss of persons having a tendency for decreased bone density, postmenopausal women, and periodontal disease patients in a maintenance phase; a method for inhibiting gingival recession of such persons; and an oral composition, an agent for preventing or treating gingival recession, and an agent for preventing or treating alveolar bone resorption and periodontal membrane loss, each comprising a soy isoflavone aglycone, calcium, and vitamin D3. BACKGROUND ART [0002] Decreased bone density is caused by aging, nutrition / diet problems such as shortage of calcium intake, lack of exercise, medicines such as adrenal corticosteroids, etc. In particular, women tend to suffer a rapid decrease of bone mass because of decreased estrogen secretion due to menopause. Here, a person having decreased bone density is one whose bone mineral density is 1 SD (Standard Deviation...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K31/59A61K31/353A61K31/352A61K31/593A61K36/48
CPCA61K31/352A61K31/593A61K33/06A61K36/48A61K2300/00A61P1/02A61P19/00
Inventor SEKIMOTO, YUKIYOOTSUKI, HIDEHIKOTAKEMURA, AKANE
Owner SUNSTAR INC
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