Aggrecanase molecules

a technology of aggrecanase and aggrecanase, which is applied in the field of nucleotide sequences encoding novel aggrecanase molecules, can solve the problems of cartilage biomechanical characteristics deficiencies, severe osteoarthritis reducing quality of life, etc., and achieves the effect of preventing aggrecan cleavage, inhibiting or antagonizing the activity of aggrecanase, and reducing the activity of aggrecan
US20070128616A1Inactive Publication Date: 2007-06-07WYETH LLC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
WYETH LLC
Publication Date
2007-06-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
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Description

RELATED APPLICATION

[0001] This application relies on the benefit of priority of U.S. provisional patent application No. 60 / 353,680, filed on Jan. 31, 2002, the entire disclosure of which is incorporated by reference.FIELD OF THE INVENTION

[0002] The present invention relates to the discovery of nucleotide sequences encoding novel aggrecanase molecules, aggrecanase proteins and fragments thereof, and processes for producing them. The invention further relates to identification and development of inhibitors of and antibodies to the aggrecanase enzymes. These inhibitors and antibodies may be useful for the treatment of various aggrecanase-associated conditions including osteoarthritis. BACKGROUND OF THE INVENTION

[0003] Aggrecan is a major extracellular component of articular cartilage. It is a proteoglycan responsible for providing cartilage with its mechanical properties of compressibility and elasticity. The loss of aggrecan has been implicated in the degradation of articular carti...

Claims

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