Container for preserving blood products at cryogenic temperatures

a technology of cryogenic temperature and container, which is applied in the field of cryogenic temperature preservation of blood or blood components, can solve the problem of higher cos

Inactive Publication Date: 2007-11-08
CHAMMAS JACQUES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Titanium can also be used to fabricate the container, but the cost could be higher.

Method used

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  • Container for preserving blood products at cryogenic temperatures
  • Container for preserving blood products at cryogenic temperatures
  • Container for preserving blood products at cryogenic temperatures

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Embodiment Construction

[0032] It is the essence of this invention to provide a durable and tough container that can reliably endure long-term storage at very low cryogenic temperature environments. Such containers are essential to preserve valuable and perishable contents such as rare blood or progenitor cells of neonatal. The present invention provides a metallic container characterized with high strength and high toughness to endure very low cryogenic temperature. It is known that cold temperatures embrittle materials causing it to fracture at much lower than normal impacts. By using tough metals that greatly minimize the effect of embrittlement, containers are capable of withstanding stresses or impacts at low temperatures.

[0033] A top view of a metallic container 20 is shown in FIG. 1. The container is generally having the shape of a rectangular parallelepiped with a large flat base and a relatively little height. The large flat base and top surfaces are referred to as planar surfaces 24. The side su...

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Abstract

Metallic containers with high toughness characteristics are utilized to cryopreserve blood products and more particularly neonatal stem and progenitor cells at cryogenic temperatures. Metallic containers with high toughness and strength characteristics are durable at low temperatures and are capable to endure high stresses and impacts at −196° C. These containers are better fit to preserve blood products without compromising their sterility or their medical integrity. Methods for fabricating metallic containers are also disclosed.

Description

FIELD OF THE INVENTION [0001] This Invention relates to cryopreservation of blood or blood components at cryogenic temperatures. BACKGROUND OF THE INVENTION [0002] It has been known in blood bank industry that long-term storage of blood components can be achieved at cryogenic temperature. Plasma can be stored for one year at −18° C. to be thawed and used for therapeutic applications. Concentrated red blood cells (RBC) treated with glycerol can be stored for 10 years at −70° C. to be used again. Recently, a new technique has been established to cryopreserve hematopoietic stem and progenitor cells of neonatal or fetal blood. These cells that have been cryopreserved and thawed can be used for autologous reconstitution. Hematopoietic stem cells treated with cryoprotectant fluids are expected to survive a long-term storage in liquid Nitrogen at −196° C. [0003] Throughout all these cryogenic preservation applications, plasma, RBC, or progenitor stem cells are stored in plastic bags of dif...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B65D25/04
CPCA01N1/0263A01N1/02
Inventor CHAMMAS, JACQUES
Owner CHAMMAS JACQUES
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