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Chemodenervating pharmaceutical as anti-inflammatory agent

a technology of chemodenervating pharmaceutical and denervating tissue, which is applied in the field of chemodenervating pharmaceutical as anti-inflammatory agent, can solve the problems of pain or subjective adverse sensory experience, inability to explain certain medical observations regarding the use of chemodenervating agents, and inability to achieve long-lasting action, reduce inflammation, and reduce inflammation

Inactive Publication Date: 2009-06-11
REVANCE THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]It has been found that the use of botulinum toxin in doses from ⅓rd to several orders of magnitude less than those associated with treatment of regional movement diseases has been effective to reduce inflammation and adverse sensory experiences associated with the inflammatory response. These observations are explained by the fact that it has been found that low dosages of the subject chemodenervative agent reduces histamine releases and releases of other preformed mediators associated with mast cell degranulation. The subject bioeffect is noted at low dosages of the chemodenervative agent in one animal model of ocular surface disease well noted for histamine release and releases of other preformed mediators associated with mast cell degranulation and rapid inflammatory response.
[0016]It has been found that Type 1 hypersensitivity reactions are reduced with the subject anti-inflammatory agent. Such hypersensitivity reactions are classic for rapid expression of the inflammatory response often leading to edema with increased vascular permeability, erythema, abnormal sensory experiences, and increased heat release.

Problems solved by technology

Unfortunately, inflammatory reactions intrinsically may have destructive effects on tissue and organ structure and function, and may lead to painful or subjectively adverse sensory experiences.
Despite the known tissue effects from regional injections of botulinum toxin, certain medical observations regarding the use of chemodenervating agents can not be easily explained by such denervating tissue effects.

Method used

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  • Chemodenervating pharmaceutical as anti-inflammatory agent
  • Chemodenervating pharmaceutical as anti-inflammatory agent
  • Chemodenervating pharmaceutical as anti-inflammatory agent

Examples

Experimental program
Comparison scheme
Effect test

case i

[0036]A 53-year-old woman had a history of Bell's Palsy five years prior to being evaluated for asymmetric facial movements from synkinesis. The facial movements were causing involuntary eyelid closure. Additionally, she noted abnormality in forehead creases and desired achieving facial forehead crease wrinkle symmetry by injection of botulinum into the frontalis muscle. After exercising, she noted that she would traditionally break out in hives, eg. urticaria, throughout her body, with the facial region being most severely involved. This urticarial reaction was closely associated with itching.

[0037]Two weeks after botulinum toxin injection at a dose of 2.5 units per injection site, an unusual phenomenon was noted on her forehead after exercising. An area measuring three to four centimeters around each injection area was protected from hive, itching or erythema. Other areas of the face were involved in the usual hive, erythema and flushing reaction experienced with exercising. The p...

case ii

[0040]A 44-year old woman with interest in having glabellar lines reduced with botulinum toxin experienced generally facial flushing and swelling sometimes associated with headache following extreme exertion. After regional botulinum toxin was administered at a dose of 5 units, an area with diameter measuring 25 mm around the injection sites was protected from the flushing and abnormal sensory effect associated with such exertion. She noted this protective effect lasted 10-14 weeks.

[0041]FIG. 2 is a photograph of this woman within three days after injection, showing the blocking effect on heat release, vasodilation, erythema and edema, which effect expands to its maximum in 12 days, and persists for at least four months.

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Abstract

Pharmaceutical application of a chemodenervating agent, particularly botulinum toxin, reduces inflammatory response and serves as an anti-inflammatory agent without systemic side effects and with long duration action, on the order of 12-24 weeks. In one embodiment, the effective dosage for allergy provoked inflammation reduction is an order of magnitude less than dosages associated with treatment of regional movement diseases, since the agent works to reduce inflammation by reducing histamine and other preformed mediator releases associated with mast cell degranulation.

Description

FIELD OF INVENTION[0001]This invention relates to the use of chemodenervating agents in the treatment of disease, and more particularly to its use as an anti-inflammatory agent.BACKGROUND OF THE INVENTION[0002]Immunity and inflammation are forms of physiologic processes defined as the body's response against foreign substances such as antigens or, in some cases, itself, autoantigens, or some form of damaging biologic or mechanical insult. The process often involves the production of antibodies by type B lymphocytes which interact with foreign substances and subsequently destroy or inactivate the antigen using a number of cellular and chemical amplification systems and regulation systems such as complement, arachidonic acid metabolites such as prostaglandin and leukotrienes, cytokines, preformed mediators such as serotonin and histamine, and enzymes. Inflammatory responses occur in conjunction and as a result of the immune recognition process and functions to provide the basic tissue...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/08A61P29/00
CPCA61K38/4893A61K45/06A61K2300/00A61P29/00
Inventor BORODIC, GARY E.
Owner REVANCE THERAPEUTICS INC
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