Water Soluble and Activable Phenolics Derivatives with Dermocosmetic and Therapeutic Applications and Process for Preparing Said Derivatives

a technology of activation and phenolics, applied in the field of preparation of phenolics derivatives, can solve the problems of difficult to reach concentration and stability, difficult to achieve concentration and stability, and difficult to achieve oxidation resistant forms of phenolics, so as to prevent carcinogenesis, reduce allergic reactions, and potent immunosuppressive effects
US20090233876A1Inactive Publication Date: 2009-09-17LIBRAGEN SA
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
LIBRAGEN SA
Publication Date
2009-09-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to the preparation of phenolics derivatives, pharmaceutic and cosmetic compositions comprising such phenolics derivatives, and their use for the beauty of the skin and for treating diseases.BACKGROUND OF THE INVENTIONPhenolic Compounds and their Properties

[0002] Phenolic compounds (also called phenolics), or polyphenols, constitute one of the most numerous and widely-distributed groups of substances in the plant kingdom, with more than 8,000 phenolic structures currently known. Polyphenols are products of the secondary metabolism of plants. The expression “phenolic compounds” embraces a considerable range of substances that possess an aromatic ring bearing one or more hydroxyl substituents. Most of the major classes of plant polyphenol are listed in Table 1, according to the number of carbon atoms of the basic skeleton. The structure of natural polyphenols varies from simple molecules, such as phenolic acids, to highly polymer...

Claims

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