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Process for the preparation of monodisperse polymer particles

a polymer particle and polymer technology, applied in the field of substantially monodisperse polymer particle preparation, can solve the problems of relatively complex and inefficient simplicized ugelstad process, and the process described in wo 92/16581 does not particularly improve upon

Inactive Publication Date: 2010-04-22
LIFE TECH AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This method allows for the production of monodisperse polymer particles with a size increase of up to 1000 times in volume, achieving uniform particle sizes from 1 to 200 μm with high precision and efficiency, reducing the complexity of previous processes.

Problems solved by technology

The processes described in EP-B-3905 and U.S. Pat. No. 4,530,956 (the disclosures of which are hereby incorporated by reference) and the simplified Ugelstad process are relatively complex and inefficient.
The processes described in WO 92 / 16581 do not especially improve upon those disclosed in EP-3-3905 and U.S. Pat. No. 4,530,956.

Method used

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  • Process for the preparation of monodisperse polymer particles
  • Process for the preparation of monodisperse polymer particles

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0079]Porous crosslinked polystyrene particles, 30 μm

[0080]1400 g of water, 84 g of dioctanoyl peroxide (DOP), 140 g of acetone and 7 g of sodium dodecyl sulphate (SDS) were homogenized in a two stage Manton Gaulin homogenizer with 380 kg / cm2 in the first stage and 100 kg / cm2 in the second stage for 8-9 min.

[0081]After homogenization 178.1 g of the emulsion were charged with a seed suspension of monodisperse oligomeric styrene particles having a particle diameter of 5 μm. There were used 21.9 g of seed suspension containing 19.8 g of water and 2.1 g of oligomeric particles.

[0082]After stirring for 3 days at 25° C., 180.8 g of the activated seed particles were charged with an emulsion containing 1683 g of water, 0.6 g of sodium dodecyl sulfate (SDS), 2.6 g of Methocel K100 (HPMC=Hydroxy Propyl Methyl Cellulose), 117 g of 80% divinylbenzene (DVB) [i.e. 80% by weight DVB, 20% by weight ethyl vinyl benzene and other byproducts of DVB production], 223 g of porogen (to 1 uene:n-heptane in...

example 2

[0086]Porous acrylic particles, 30 μm

[0087]1400 g of water, 84 g of DOP, 140 g of acetone and 7 g of SDS were homogenized in a two stage Manton Gaulin homogenizer with 380 kg / cm2 in the first stage and 100 kg / cm2 in the second stage for 8-9 min.

[0088]After homogenization, 88.4 g of the emulsion were charged with a seed suspension of monodisperse oligomeric styrene particles having a particle diameter of 5 μm. There were used 9.6 g of seed suspension containing 8.75 g of water and 0.85 g of oligomeric particles.

[0089]After stirring for 3 days at 25° C., 89 g of the activated seed particles were charged with an emulsion containing 844 g of water, 1.3 g of Methocel K100, 44.9 g of ethylene dimethylacrylate (EDMA), 11.4 g of hydroxy ethyl methacrylate (HEMA), 113 g of porogen (cyclohexanol: butylacetate in a 1:1 volume ratio). The mixture was emulsified with a Ultra Turrax at maximum speed for 10 min.

[0090]After swelling for 2 hrs at 25° C., 0.4 g of potassium iodide (KI) dissolved in 3...

example 3

[0091]Solid polystyrene particles, 20 μm

[0092]1400 g of water, 84 g of DOP, 140 g of acetone and 7 g of SDS were homogenized in a two stage Manton Gaulin homogenizer with 380 kg / cm2 in the first stage and 100 kg / cm2 in the second stage for 8-9 min.

[0093]After homogenization 159 g of the emulsion were charged with a seed suspension of monodisperse oligomeric styrene particles having a particle diameter of 5 μm. There were used 43.9 g of seed suspension containing 39.7 g of water and 4.2 g of oligomeric particles.

[0094]After stirring for 2 days at 25° C., 184.4 g of the activated seed particles were charged with an emulsion containing 836 g of water, 1.5 g of Methocel K100, 348.8 g styrene. The emulsion was homogenized at 400 kg / cm2 in the first stage and 100 kg / cm2 in the second stage for 4-5 min.

[0095]After swelling for 2 hrs at 25° C., 3 g of Methocel K100 dissolved in 427 g of water were charged to the reactor and then the dispersion was polymerized for 1 hr at 60° C. and 9 hrs at...

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Abstract

A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers / oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation of co-pending U.S. patent application Ser. No. 09 / 958,431, filed Oct. 9, 2001, which is a national stage filing under 35 U.S.C. 371 of PCT / GB00 / 01334, filed Apr. 10, 2000, which claims priority to GB9908163.0, filed Apr. 9, 1999 and GB0007008.6, filed Mar. 22, 2000.FIELD OF THE INVENTION[0002]This invention relates to improvements in and relating to the preparation of substantially monodisperse polymer particles.DESCRIPTION OF RELATED ART[0003]Monodisperse polymer particles (i.e. particles with a coefficient of variation of less than 10%, preferably less than 5% and more preferably less than 3%) have been commercially available for several years and find applications in many technical fields, e.g. in pharmaceuticals, in separation processes, as toners, as filters, as spacers, etc.[0004]Polymer beads may be produced by diffusing a monomer and a polymerization initiator (or catalyst) into polymer se...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C08F2/10C08L39/06C08L23/00C08L79/02C08L1/26C08F2/26C08F257/02C08F265/04C08F291/00
CPCC08F257/02C08F265/04C08J9/224C08F291/00C08J9/16C08F265/10C08F2/22C08J9/22C08J2203/14C08J2325/06C08J2347/00
Inventor JORGEDAL, ARNEAKSNES, ELIN MARIEFONNUM, GEIRELLINGSEN, TURIDBERGE, ARVID TRYGVEUGELSTAD, JOHNUGELSTAD, VIOLAMOLTEBERG, ASTRID EVENRODNORDAL, ROLFPETTERSEN, HENNINGTAARNEBY, TOLLEFSTAALE, SOLVEIG MARIEWENG, ELLENHANSEN, FINN KNUTNORDBO, SILJE STEINBAKKAUNE, ODDVAR ARNFINNBJORGUM, JOHN OLAV
Owner LIFE TECH AS