Abscissic acid and derivatives thereof for the treatment of diseases
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ABA is a More Potent Inducer of FH than RTA
[0084]Ferritin H (FH) can suppress globin expression and chelate iron. The inventors have developed methods of fusing cells in vitro for the purpose of creating cross-species developmental erythroid heterokaryons. Fusing nucleated adult erythroid cells of one species with embryonic / larval erythroid cells of another species led to cross induction of developmentally-specific patterns of globin gene expression, providing evidence for developmental stage-specific trans-acting factors (Barker-Harrel et al., 1988; Broyles et al., 1989). In addition to detecting cross-activation of globin genes, cross-repression was also evident in some experiments involving heterokaryons (Broyles et al., 1994). These results led to a search for a repressor of the human adult β-globin gene, the gene mutated in sickle cell disease. The inventors noted that human K562 cells, an erythroleukemia line that expresses embryonic and fetal globins but no adult β-globin, co...
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