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Method of Oxidization Using Nitric Acid

a technology of nitric acid and oxidizing method, which is applied in the field of oxidizing method using nitric acid, to achieve the effect of reducing thermal control problems, improving product isolation, and being readily availabl

Inactive Publication Date: 2010-07-29
KIELY DONALD E +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This method prevents exothermic reactions, recycles NOx gases, and simplifies product isolation, making carbohydrate acids more economically viable for industrial production and increasing their availability.

Problems solved by technology

Furthermore, many aldaric acids that were previously unavailable are now capable of industrial production and commercial development.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

General Methods

[0031]Solutions were concentrated in vacuo (10-15 mbar) using a rotary evaporator and water bath at 50° C. pH measurements were made with a Thermo Orion 310 pH meter (Thermo Fisher Scientific, Inc., Waltham, Mass., USA) which was calibrated prior to use. Oxidations were carried out in Mettler Toledo Labmax reactor. The Labmax reactor is designed to operate as a computer controlled closed-system reactor. The Labmax was fitted with a top-loading balance, a liquid feed pump, an oxygen Sierra flow valve, a mechanically driven stirring rod, a thermometer, a 1 liter thermal jacketed flask, a FTS recirculating chiller, a pressure manifold fitted with pressure relief valves and pressure gauge and a personal computer with CamileTG v1.2 software. The software installed allows the operator to program experiments based on specific parameters and conditions.

example 2

Nitric Acid Oxidation of D-Glucose

[0032]The aqueous 62.3% D-glucose solution used in the oxidations was prepared by adding solid D-glucose (162.5 g, 0.75 mol) to 97.5 grams of deionized water in a screw-capped flask containing a stir bar. Prior to adding solid D-glucose to the water, the water was heated to ca. 60° C. with stirring. Once the D-glucose was dissolved, the temperature was reduced to ambient and dry sodium nitrite (0.60 g) added to the solution. The total weight of the solution is 260.6 g.

[0033]The Recipe Menu is accessed using the Labmax CamileTG v1.2 software and the reaction parameters for the oxidation were programmed in a series of stages: Stage 1—the reactor temperature was set at 25° C.; the stirring rod speed set at 200 rpm (and held constant throughout all the remaining stages); time set for 1 minute. Stage 2—the reactor temperature was set at 25° C., and the pressure set at 0.25 bar for a duration of 3 minutes. Stage 3—the temperature of the reactor was set at...

example 3

Nitric Acid Oxidation of D-Glucose

[0037]The oxidation of D-glucose was carried out as in Example 1. However, potassium hydroxide was substituted for sodium hydroxide in the neutralization process to give crude D-glucaric acid dipotassium salt (151.25 g, 70.4% based on pure dipotassium D-glucarate). The salt was precipitated from methanol as described to give an off white solid (145.75 g, 67.9% based on pure dipotassium D-glucarate).

[0038]Monopotassium D-glucarate isolation, Method 1. D-Glucose (162.5 g, 0.75 mol) was oxidized using the LabMax reactor and concentrated as described. The concentrate of organic product(s) and residual nitric acid was diluted with deionized water (150 mL) and chilled at 5° C. for 18 h. The pH of the solution was adjusted to a constant pH of 9.1 with 45% KOH (184 mL) in an ice bath and the solution back-titrated to pH 3.4 with concentrated HNO3 (34.6 mL) in an ice bath. A precipitate formed when the solution pH dropped below 5. After cooling the mixture a...

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PUM

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Abstract

A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids. Oxidation of some carbohydrates by this process can produce one or more of their corresponding acid forms. The process is carried out at moderate temperatures, typically in the range of 20° C. to 45° C. in a closed reactor, with oxygen gas being introduced into the reaction chamber as needed in order to sustain the reaction. Computer controlled reactors allow for careful and reproducible control of reaction parameters. Nitric acid can be recovered by a distillation / evaporation process, or by diffusion dialysis, the aqueous solution made basic with inorganic hydroxide, and the residual inorganic nitrate removed using a filtration (nanofiltration) device. The method eliminates issues of thermal control of the oxidation, release of nitrogen into the atmosphere, and post-reaction difficulties in the removal of nitric acid and inorganic nitrates.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of co-pending U.S. patent application Ser. No. 11 / 890,760, filed Aug. 6, 2007, which claims the benefits of U.S. Provisional Patent Application No. 60 / 836,329, filed Aug. 7, 2006, the disclosure of which is hereby incorporated by reference in its entirety including all figures, tables and drawings.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]This invention was made with Government support under Grant No. 2001-344463-10521 awarded by the USDA. The Government has certain rights in the invention.REFERENCE TO SEQUENCE LISTING, A TABLE, OR A COMPUTER PROGRAM LISTING COMPACT DISC APPENDIX[0003]Not applicable.TECHNICAL FIELD[0004]This invention describes a method for synthesizing carbohydrate acids through controlled oxidation of their corresponding carbohydrates using nitric acid and oxygen as the oxidizing agents.BACKGROUND OF THE INVENTION[0005]Carbohydrate acids, and in particular ca...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D309/30C07C55/02
CPCC07C51/27C07C59/285C07C51/00
Inventor KIELY, DONALD E.HASH, SR., KIRK R.
Owner KIELY DONALD E
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