Compositions for skin diseases or disorders
a technology for skin diseases and disorders, applied in the field of cosmetic compositions, can solve the problems of many vitamin d antagonists, such as cortisone, severe side effects, and compounds and their formulations, and achieve the effect of increasing the level of amps
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example 1
Extraction Process
[0063]Crushed dry leaves of Tambourissa trichophylla are extracted with a mixture of ethanol and water (in a volume ratio of 70:30). The mixture is stirred and heated at a temperature below 60° C. for a period of about 30 minutes to about 1 hour to perform the extraction. The solid plant material is removed, and ethanol is then removed leading to a precipitate, which is filtered out of the remaining aqueous solution. The aqueous solution is then treated by liquid-liquid extraction with ethyl acetate. The acetate fraction is retained for acetate distillation and the consequent aqueous solution is freeze-dried.
[0064]The final extract is characterized by thin layer chromatography (TLC), using HPLC standard methods and spectrophotometry. The final composition shows a content of 19% to 21% by weight of polyphenols and less than 2% by weight rutin and nicotiflorine. The presence of epicatechin is also detected by TLC.
example 2
Cosmetic Formulation Examples
[0065]Emulsions containing various concentrations of Tambourissa trichophylla leaf extract were prepared in accordance with Example 1. The emulsion concentrations are set forth in Table 1. Phases A and B of the emulsions were weighed separately. The separate phases (A & B) were heated to 80° C. and mixed under high stirring A to B. The mixture was cooled down to 35° C. while stirring and component C was added. The compounds listed members of component D were mixed until a transparent solution was obtained and component D was then added to the formulation. The final formulation was cooled down to room temperature while stirring continued.
[0066]The final compositions were cosmetic oil in water emulsions: excipient (A) was white and formulations containing extract according to Example 1 (B & C) were beige to beige-orange.
TABLE 1Emulsions of Example 2BCAExcipient +Excipient +INCI NameExcipient0.3% extract0.5% extractAGlyceryl Stearate + PEG-2.002.002.00100 S...
example 3
Anti-Inflammatory Activity on Prostaglandin-2 (PGE-2)
[0067]A test was performed on HUVEC (human umbilical vein endothelial cells). HUVEC were incubated for 24 hours without (control) or with various concentrations of the extract from to example 1, and in presence of an inducer: VEGF (venous endothelial growth factor). PGE-2 levels were measured in the medium by the ELISA method. Significance was evaluated by the Student test.
TABLE 2Inhibitory activity of Tambourissa trichophylla leaf extract accordingto Example 1 on PGE-2 synthesis by HUVECPGE-2Variation(pg / μgtowards control +proteins)VEGF (%)SignificanceControl without VEGF1.84——Control with VEGF10.78——Tambourissa0.5 μg / ml 11.66 +8%NSextract in1 μg / ml6.11−43%**p presence of5 μg / ml8.91−17%**p VEGF**significantly different from the control with VEGF (p
[0068]The Tambourissa plant extract in the medicament or cosmetic composition of the invention can significantly modulate the cyclooxygenase pathway and therefore can have positive in...
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