Methods of manufacturing cartilage products

Abstract

This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to:[0002]U.S. Provisional Application No. 61 / 670,444, entitled “Methods of Manufacturing Cartilage Products,” filed on Jul. 11, 2011 bearing Docket No. 25534US01 in the office of McAndrews, Held and Malloy;[0003]U.S. Provisional Application No. 61 / 670,434, entitled “Disrupted Cartilage Products,” filed on Jul. 11, 2011 bearing Docket No. 25533US01 in the office of McAndrews, Held and Malloy; and[0004]U.S. Provisional Application No. 61 / 670,424, entitled “Porated Cartilage Products,” filed on Jul. 11, 2011 bearing Docket No. 25532US01 in the office of McAndrews, Held and Malloy; the contents of which are hearby incorporated by reference in their entireties.[0005]This application is being co-filed with U.S. and PCT Applications entitled “Porated Cartilage Products” bearing Docket Nos. 25532U502 and 25532WO01 in the office of McAndrews, Held and Malloy, respectively; U.S. and PCT Applications entitled “Disrup...

AI Technical Summary

Benefits of technology

The patent text describes a method of making a cartilage sample more flexible by adding small pores to it. The pores are made by using a special tool to make small punctures in the cartilage sample. The size of the pores can be controlled, and there can be a certain number of pores per unit area. The process can affect the arrangement of the cells in the cartilage sample. Overall, this method makes it easier to manipulate the cartilage sample for further study.

Problems solved by technology

Articular cartilage injury remains one of the major unsolved problems in orthopedics.

However, many of these surgeries yield suboptimal results.

If the lining becomes worn or damaged resulting in lesions, joint movement may be painful or severely restricted.

Whereas damaged bone typically can regenerate successfully, hyaline cartilage regeneration is quite limited.

Although the blood clot introduces inflammatory cytokines, growth factors and MSCs to fill the defect, the process fails to produce articular cartilage and instead stimulates the production of fibrocartilage scar tissue, made from collagen type I. Fibrocartilage has poor long-term biomechanical performance, causes abnormal bone growth, and increases risk of osteoarthritis.

Among other shortcomings, Chen et al. do not teach a flexible cartilage implant or a cartilage implant containing viable native chondrocytes or a non-immunogenic cartilage implant.

Among other shortcomings, Steinwachs et al. do not teach a digested cartilage implant or a non-immunogenic cartilage implant.

Among other shortcomings, Bardos et al. do not teach a digested cartilage sample or a non-immunogenic cartilage sample.

Among other shortcomings, Bravenboer et al. do not teach a cartilage sample comprising a plurality of pores or a non-immunogenic cartilage sample.

Among other shortcomings, Bos et al. do not teach a cartilage sample comprising a plurality of pores or a non-immunogenic cartilage sample.

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