Disrupted cartilage products

Abstract

This invention provides disrupted cartilage products, methods of manufacturing disrupted cartilage products, and methods of treating a subject comprising administering a cartilage product. The cartilage products are manufactured by a method comprising disrupting a collagen matrix, e.g. to produce a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to:[0002]U.S. Provisional Application No. 61 / 670,434, entitled “Disrupted Cartilage Products,” filed on Jul. 11, 2011 bearing Docket No. 25533US01 in the office of McAndrews, Held and Malloy;[0003]U.S. Provisional Application No. 61 / 670,424, entitled “Porated Cartilage Products,” filed on Jul. 11, 2011 bearing Docket No. 25532US01 in the office of McAndrews, Held and Malloy; and[0004]U.S. Provisional Application No. 61 / 670,444, entitled “Methods of Manufacturing Cartilage Products,” filed on Jul. 11, 2011 bearing Docket No. 25534US01 in the office of McAndrews, Held and Malloy; the contents of which are hearby incorporated by reference in their entireties.[0005]This application is being co-filed with a U.S. and PCT Applications entitled “Methods of Manufacturing Cartilage Products” bearing Docket Nos. 25534US02 and 25534WO01 in the office of McAndrews, Held and Malloy, respectively; U.S. and PCT Applicatio...

AI Technical Summary

Benefits of technology

[0039]the cartilage sample is mechanically disrupted to an extent that increases flexibility of the cartilage sample;

[0043]In one embodiment, the cartilage sample is mechanically disrupted to an extent that increases flexibility of the cartilage sample. Optionally, the mechanical disruptions are provided which disrupt (i.e. extend through) the entirety of the thickness of the cartilage sample. Optionally, the mechanical disruptions are provided which do not disrupt the entirety of the thickness of the cartilage sample.

Problems solved by technology

Articular cartilage injury remains one of the major unsolved problems in orthopedics.

However, many of these surgeries yield suboptimal results.

If the lining becomes worn or damaged resulting in lesions, joint movement may be painful or severely restricted.

Whereas damaged bone typically can regenerate successfully, hyaline cartilage regeneration is quite limited.

Although the blood clot introduces inflammatory cytokines, growth factors and MSCs to fill the defect, the process fails to produce articular cartilage and instead stimulates the production of fibrocartilage scar tissue, made from collagen type I. Fibrocartilage has poor long-term biomechanical performance, causes abnormal bone growth, and increases risk of osteoarthritis.

Chen et al. do not teach a flexible cartilage implant or a cartilage implant containing viable native chondrocytes or a non-immunogenic cartilage implant.

Among other shortcomings, Steinwachs et al. do not teach a digested cartilage implant or a non-immunogenic cartilage implant.

Bardos et al. does not teach a spiral cut cartilage sample or a non-immunogenic cartilage sample.

Among other shortcomings, Bravenboer et al. do not teach a mechanically disrupted cartilage sample or a non-immunogenic cartilage sample.

Bos et al. does not teach a mechanically disrupted cartilage sample or a non-immunogenic cartilage sample.

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