Combination of 25-hydroxyvitamin d and Anti-inflammitories for sustained plasma 17- ß estradiol levels

Abstract

This invention relates to the use of the combination of 25-hydroxyvitamin D3 (“25-OH D3”) and antioxidants (ascorbic acid vitamin E and canthaxanthin) to make a premix or feed for use in maintain, increasing, or ameliorating the decrease of 17 β-estradiol levels in poultry which are observed when poultry is fed ad libitum, thereby extending the poultry's egg laying life.

Description

BRIEF DESCRIPTION OF THE INVENTION[0001]This invention relates to the combination of 25-hydroxyvitamin D (“25-OH D3” and / or “25-OH D2”) and antioxidants / anti-inflammatories (ascorbic acid, Vitamin E and canthaxanthin) for use in poultry feed for sustaining 17-β-estradiol levels of female birds, thereby extending their productive lifetime as egg layers. It also relates to feed and feed premixes containing the combination of 25-hydroxyvitamin D and the antioxidants / anti-inflammatories for this use.BACKGROUND OF THE INVENTION[0002]Reproductive efficiency and the incidence of pathogenic disorders are directly influenced by the extent of ovary development and nutrition in poultry. For example, the finely tuned reproductive system of the broiler breeder female requires ovary, oviduct, brain, liver and skeletal system to communicate among themselves under the influence of lighting in the production of hatching eggs. The hypothalamus, located within the brain, is directly stimulated by ligh...

AI Technical Summary

Benefits of technology

The patent describes a method for improving the lifespan and productivity of poultry by adding a combination of 25-OH D and antioxidants / anti-inflammatories to its basal diet. This combination can lead to a decrease in obesity, which is associated with decreased 17-β estradiol levels and shorter lifespan in poultry. By maintaining or increasing 17-β estradiol levels, the use of this combination can improve bone health, gut health, liver and ovarian health, which are all linked to sustained egg production. This results in a more durable and healthy egg production process.

Problems solved by technology

Therefore, the challenge of managing modern female broiler breeder strains is the inability of these hens to adequately self-regulate feed intake during growth and development to achieve an optimal body weight and composition to support efficient egg and chick production.

As such, broiler breeder females are subject to a high degree of restricted feeding regimen.

Broiler breeder females overfed during reproductive development not only produce excess large yellow ovarian follicles but also generate a greater number of atretic yellow follicles and commonly display erratic oviposition and defective egg syndrome (EODES) that include several reproductive problems such as follicular atresia, the production of soft-shelled or membranous eggs, double-yolked eggs, egg yolk peritonitis (presence of egg yolk in the abdominal cavity), multiple egg days and oviposition not occurring in sequence, resulting in increased production of unsettable eggs.

Controlled studies reported that voluntary feeding (i.e., broiler breeder hens to satiation) resulted in poor egg production, high rate of mortality and abnormal ovarian structure (mainly overt hierarchical follicle atresia.

Despite restricted feeding regimen strictly implemented in commercial broiler breeder flocks, it is still very easy to overfeed breeder hens due to their intrinsic hyperphagia.

There is no teaching to add ascorbic acid to the combination, nor for its use in ameliorating the adverse effects of hyperphagia on 17-β estradiol levels.