Coating film having thinly-spreading and irregularity-conforming properties, and structural base having such film

Pending Publication Date: 2019-07-18
NISSAN CHEM IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is a structural base that includes a coating film that prevents biomaterial adhesion, such as proteins and cells. The coating film is made of a specific polymer that inhibits adhesion. The film can be applied to various materials including glass, metals, and resins and can be fixed firmly to plastics. The coating film is uniform and conformal, with a difference between the maximum film thickness and the minimum film thickness of not more than 1500 Å. This makes it useful in applications where biomaterial adhesion is not desired, such as cell culture vessels. The coating film is not significantly thicker at the edge or bottom of the structural portion, which ensures accurate optical measurement. Overall, the invention provides a structural base with improved resistance to biomaterial adhesion.

Problems solved by technology

The use of fiber optic faceplates for chemical reactions and bioassays has encountered problems (such as, for example, optical bleeding and physical interferences between neighboring reaction chambers).

Method used

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  • Coating film having thinly-spreading and irregularity-conforming properties, and structural base having such film
  • Coating film having thinly-spreading and irregularity-conforming properties, and structural base having such film
  • Coating film having thinly-spreading and irregularity-conforming properties, and structural base having such film

Examples

Experimental program
Comparison scheme
Effect test

synthetic example 1

[0220]While keeping the temperature at 60° C., 28.00 g of acid phosphoxyethyl methacrylate (product name: Phosmer M manufactured by Uni-Chemical Co., nonvolatile content measured by drying process at 100° C. for 1 hour: 91.8%, mixture of acid phosphoxyethyl methacrylate (44.2 mass %), bis[2-(methacryloyloxy)ethyl]phosphate (28.6 mass %) and others (27.2 mass %)) was stirred, and 21.37 g of 2-(dimethylamino)ethyl methacrylate was added thereto dropwise. While keeping the temperature at not more than 20° C., 133.96 g of pure water, then 44.65 g of ethanol (manufactured by Tokyo Chemical Industry Co., Ltd.) and 0.25 g of 2,2′-azobis(N-(2-carboxyethyl)-2-methylpropionamidine) n-hydrate (product name: VA-057 manufactured by Wako Pure Chemical Industries, Ltd.) were added to the mixture sequentially. The resultant mixture was sufficiently stirred to uniformity. The mixture liquid thus obtained which contained the above materials was introduced into a dropping funnel. Separately, 267.93 g ...

synthetic example 2

[0221]29.95 g of choline (48-50% aqueous solution manufactured by Tokyo Chemical Industry Co., Ltd.) was added to 25.00 g of acid phosphoxyethyl methacrylate (product name: Phosmer M manufactured by Uni-Chemical Co., nonvolatile content measured by drying process at 100° C. for 1 hour: 91.8%, mixture of acid phosphoxyethyl methacrylate (44.2 mass %), bis[2-(methacryloyloxy)ethyl] phosphate (28.6 mass %) and others (27.2 mass %)) while performing cooling so that the temperature was 35° C. or below. The resultant mixture was stirred to uniformity. While keeping the temperature at not more than 35° C., 20.95 g of an 80% aqueous methacryloylcholine chloride solution (manufactured by Tokyo Chemical Industry Co., Ltd.), 28.67 g of butyl methacrylate (manufactured by Tokyo Chemical Industry Co., Ltd.), 0.70 g of 2,2′-azobis(2,4-dimethylvaleronitrile) (product name: V-65 manufactured by Wako Pure Chemical Industries, Ltd.) and 110.84 g of ethanol were added to the mixture liquid sequentiall...

example 1

[0222]28.73 g of pure water, 13.95 g of ethanol, and 0.85 g of a 1 mol / L aqueous sodium hydroxide solution (1 N) (manufactured by KANTO CHEMICAL CO., INC.) were added to 5.00 g of the copolymer-containing varnish obtained in Synthetic Example 1. The mixture was sufficiently stirred to give a coating agent. The pH was 7.5. A commercial silicon wafer for semiconductor evaluation, and a culture plate (Corning (registered trademark) #351172 (96 wells, volume 0.37 mL) (material: polystyrene) were dipped into the coating agent and were dried in an oven at 50° C. for 24 hours. Thereafter, the wafer and the plate were sufficiently washed with pure water. Thus, coating films were formed on the silicon wafer and the plate. The film thickness of the coating film on the silicon wafer was measured with an ellipsometer to be 147 Å.

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Abstract

The invention provides a structural base that includes a coating film on at least a portion of the surface thereof, the coating film having a difference between the maximum film thickness and the minimum film thickness of not more than 1000 Å. A method of the invention produces such structural bases. The coating film includes a copolymer including a repeating unit containing a group represented by formula (a), and a repeating unit containing a group represented by formula (b):wherein Ua1, Ua2, Ub1, Ub2, Ub3 and An− are as defined herein.

Description

TECHNICAL FIELD[0001]The present invention relates to a structural base which has, on at least a portion of the surface thereof, a coating film with a difference between the maximum film thickness and the minimum film thickness of not more than 1000 Å, and to a method for manufacturing such structural bases.BACKGROUND ART[0002]Structural bases made of various materials are coated with films to modify the properties of the surface in accordance with needs. The development of a variety of coating agents has increasingly expanded the applications of such coating techniques. For example, conformal coating agents are capable of forming a coating even along the surface of a structural base having a complicated shape. The development and marketing of such conformal coating agents range from electronic materials to medical materials.[0003]For example, microwell plates are experimental and testing tools which are flat plates having a multiplicity, such as 6, 24, 96 or 384, of pockets (holes ...

Claims

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Application Information

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IPC IPC(8): C09D133/14C12M1/00C12M1/32C09D165/04G01N21/77C12M1/22C09D133/26C08G61/04
CPCC09D133/14C09D133/26C09D165/04G01N21/7703C12M23/10C12M23/20C12M23/12C08G2261/12C08G2261/143C08G2261/147C08G61/04B05D1/18B05D1/185B05D3/0272B05D3/144B05D5/08B05D2401/21B05D7/24C09D5/1668C09D143/02B05D3/00C12M3/00C12M1/34C12M1/00
Inventor HIROI, YOSHIOMIABE, NATSUKINISHINO, TAITO
Owner NISSAN CHEM IND LTD
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