Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Formulation based on vitamin e or an ester thereof for treating bacterial and fungal biofilms

a technology of bacterial and fungal biofilms and formulations, applied in the field of formulations based on vitamin e or an ester thereof, can solve the problems of difficult diagnosis, difficult treatment and elimination of the microbial community, and difficulty in prevention, and achieve the effect of reducing the formation of pathogenic bacterial and/or fungal biofilms

Inactive Publication Date: 2020-11-19
BIO LO GA
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a new formulation for skincare products that stops harmful bacteria and fungi from growing there. This is made up of vitamin E or an ester thereof.

Problems solved by technology

The severity of such infections lies in the difficulty of diagnosis, in the difficulty of treating and eradicating the microbial community, as well as in the difficulty of prevention.
Indeed, the resistance of this particular microbial community, often of the bacterial type, is considerable and the infections that result therefrom can sometimes cause death.
The treatment of the biofilm-related infections is particularly difficult since the bacteria in this growth mode are intrinsically resistant to antimicrobial drugs and host defences.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Formulation based on vitamin e or an ester thereof for treating bacterial and fungal biofilms
  • Formulation based on vitamin e or an ester thereof for treating bacterial and fungal biofilms

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0044]An example of formulation that can be used for removing, reducing or inhibiting a bacterial and / or fungal biofilm is the product VEA® Olio, marketed by the firm Hulka S.r.l. from Rovigo and consisting of alpha-tocopheryl acetate.

example 2

[0045]A formulation according to the invention in the form of a hydrophobic gel was prepared according to the following composition, wherein the percentages are by weight on the total composition weight.

Pentamer cyclomethicone 24539.5%Vitamin E acetate30.0%Hydrogenated castor oil10.5%Octyl palmitate10.0%8:2 Cyclomethicone / dimethiconol10.0%

[0046]Such formulation was made according to the following procedure.

[0047]525 g of hydrogenated castor oil (Cutina HR) and 500 g of octyl palmitate were introduced into a steel-turbine mixer (manufactured by Dumec), and the content was stirred while being heated at about 80-90° temperature until the hydrogenated castor oil dissolved.

[0048]Then, 1500 g of vitamin E acetate were added under stirring at the above temperature, and the vacuum was produced inside the mixer (vacuum equal to 600 cmHg).

[0049]Once the desired degree of vacuum had been achieved, 500 g of a pre-formed mixture of 8:2 pentamer cyclomethicone / dimethiconol and 1975 g of pentamer ...

example 3

[0053]Another formulation according to the invention in the form of a hydrophobic gel was prepared according to the following composition, wherein the percentages are by weight on the total composition weight.[0054]tocopheryl acetate: 30%[0055]shea butter: 24%[0056]triglyceride of caprylic and capric acid: 21.7%[0057]sorbitan olivate: 14%[0058]phytosterols: 10%[0059]ceramide-NP: 0.3%

[0060]The method of preparation is as follows: a first phase comprising Vitamin E, phytosterols and ceramides is prepared by heating the whole mixture up to 120° C. to obtain a homogeneous solution. The other ingredients are heated up to 60° C. in a separate container. The two phases are then combined together and mixed for about 30 minutes at room temperature.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
temperaturesaaaaaaaaaa
temperaturesaaaaaaaaaa
temperaturesaaaaaaaaaa
Login to View More

Abstract

Formulation for topical use based on vitamin E or an ester thereof for use in removing, reducing or inhibiting a bacterial and / or fungal biofilm, wherein said ester of vitamin E is an ester with a carboxylic acid of formula R—COOH, in which R is an alkyl radical having from 1 to 19 carbon atoms, or an alkenyl or alkynyl having from 2 to 19 carbon atoms.

Description

FIELD OF APPLICATION[0001]The present invention refers to the technical field of the pharmaceutical industry.[0002]In particular, the invention refers to a formulation for topical application for the treatment of a biofilm of pathogenic bacteria or fungi.PRIOR ART[0003]It is known that a biofilm is a complex aggregation of microorganisms characterized by the secretion of an adhesive and protective extracellular matrix, defined EPS (extracellular polymeric substances).[0004]Said matrix is not a static structure, since it is subjected to considerable variations depending on the type of microorganism that produces it and the growing conditions, although it is possible to identify the recurring presence of some polysaccharides, proteins and nucleic acids, and it represents a high percentage, varying from 50% to 90%, of the organic component of the biofilm, so much to be considered the primary element of this structure.[0005]The biofilm can be present in any natural and artificial enviro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/355A61K9/00A61K47/34A61P31/04
CPCA61P31/04A61K9/0014A61K31/355A61K47/34A61K47/14A61K47/24A61P31/10A61K9/06A61P31/02
Inventor PANIN, GIORGIO
Owner BIO LO GA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com