Unlock instant, AI-driven research and patent intelligence for your innovation.

System and method for sensing analytes in gmr-based detection of biomarkers

a biomarker and analyte technology, applied in the field of systems and methods for sensing analytes in gmr-based detection of biomarkers, analyte sensing, can solve the problem of challenging reliable analyte sensing

Pending Publication Date: 2021-05-06
ZEPTO LIFE TECH LLC
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes a method for detecting the presence of an analyte using a GMR sensor. The sensor has a biomolecule that binds to a detection protein, which also binds to the analyte. When the analyte is present, it prevents the detection protein from binding to the biomolecule, and a reporter protein is added that binds to both the detection protein and magnetic nanoparticles. The reporter protein is detected using magnetic particles, and the presence of the analyte is measured by measuring the resistance change of the GMR sensor. This method allows for sensitive and cost-effective detection of various analytes.

Problems solved by technology

Reliable analyte sensing remains a challenge.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • System and method for sensing analytes in gmr-based detection of biomarkers
  • System and method for sensing analytes in gmr-based detection of biomarkers
  • System and method for sensing analytes in gmr-based detection of biomarkers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0055]As evident by the drawings and below description, this disclosure relates to a sample handling system (or “system” as noted throughout this disclosure) which may be used for detecting presence of an analyte (or analytes) in a sample. In an embodiment, this system, depicted as system 300 in FIG. 3, may include (1) a sample handling system or “cartridge assembly” that includes sample preparation microfluidic channel(s) and at least one sensing device (or sensor) for sensing biomarkers in a test sample, and (2) a data processing and display device or “cartridge reader unit” that includes a processor or controller for processing any sensed data of the sensing device of the cartridge assembly and a display for displaying a detection event. Together these two components make up the system. In an embodiment, these components may include variable features including, without limitation, one or more reagent cartridges, a cartridge for waste, and a flow control system which may be, for e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
magneticaaaaaaaaaa
resistanceaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

Methods of detecting the presence of an analyte in a query sample include providing a sensor that includes biomolecules disposed on a polymer-coated surface of a giant magnetoresistance (GMR) sensor. Modes of operation remove or add magnetic beads from the vicinity of the sensor surface by interactions with the biomolecules. The methods feature detecting the presence of the analyte in the query sample by measuring resistance change of the GMR sensor based on determining resistance before and after passing magnetic particles over the sensor.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application No. 62 / 711,396 filed Jul. 27, 2018, which is incorporated herein by reference in its entirety.INTRODUCTION[0002]The present disclosure is generally related to systems and methods for sensing analytes in water and biological samples. In particular, the present disclosure relates to analyte sensing using methods of detection based on Giant Magneto-Resistive (GMR) sensors.[0003]GMR sensors enable development of multiplex assays with high sensitivity and low cost in a compact system, and therefore have the potential to provide a platform suitable for a wide variety of applications. Reliable analyte sensing remains a challenge. The present disclosure provides exemplary solutions.SUMMARY[0004]In some aspects, embodiments herein relate to methods of detecting the presence of an analyte in a query sample comprising providing a sensor comprising a biomolecule disposed on a pol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): G01N27/12G01N33/487G01N33/49G01N33/543G01N33/18
CPCG01N27/12G01N33/48707G01N33/1813G01N33/54306G01N33/49G01R33/09G01R33/1276G01R33/1269G01R33/093B01L3/50273B01L2400/0487B01L2300/0819B01L2400/043B01L3/502715G01N2035/00148G01N35/00029G01N35/1097G01N2001/386G01N35/0098G01N27/745G01N33/543G01N33/54366G01N33/54326G01N33/84G01R33/091G01R33/0041B01L2200/026B01L2200/04B01L2200/14B01L2200/16B01L2300/025B01L2300/0816B01L2400/06G01N27/74G01N33/493B01L3/567B01L2200/027B01L2200/0684B01L2300/0663B01L2300/0681B01L2300/0883B01L2300/0887B01L2300/123B01L2300/14
Inventor KLEIN, TODD MICHAELWANG, WEISU, YI-HSUANSTUYVENBERG, IANMENDONSA, GEMMA ROSELLE
Owner ZEPTO LIFE TECH LLC