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Nanosilica carrier with spions and a curcuminoid

a carrier and curcuminoid technology, applied in the field of nanomedicine, molecular imaging, and drug delivery, can solve the problems of poor pharmacokinetic properties of curcumin, and the method of using curcumin also suffers from a lack of a tracking ability of tissues that take up curcumin, so as to reduce the viability of cancer cells.

Active Publication Date: 2021-10-21
IMAM ABDULRAHRNAN BIN FAISAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a new way to deliver curcumin to cancer cells that reduces their viability. The invention uses nanoparticles made of silica and iron oxide that can be directed to target specific tissues. The nanoparticles can also carry other chemotherapy drugs and can be coated with polymers to make them more biocompatible. This can help to better treat cancer and to track and target the specific cells that are taking up curcumin.

Problems solved by technology

Curcumin has poor pharmacokinetic properties as it is relatively insoluble in aqueous media including blood plasma and tissue fluids.
Treatment methods using curcumin also suffer from a lack of an ability to track tissues that take up curcumin.

Method used

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  • Nanosilica carrier with spions and a curcuminoid
  • Nanosilica carrier with spions and a curcuminoid
  • Nanosilica carrier with spions and a curcuminoid

Examples

Experimental program
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Effect test

example 1

Nanoporous Silica Platforms and Silica-SPION-Curcumin Compositions

[0097]Various kinds of nanoporous silica platforms, namely Q-10, Si-MCM-41, Si-SBA-16, MSU cellular foam, Si-KIT-6, ULPFDU-12 and silicalite, were hybridized with 10 wt % Fe SPIONs to form magnetically responsive silica through enforced adsorption technique. Curcumin was loaded into or onto the magnetic silica through an equilibrium adsorption technique.

[0098]The phase, textural and morphological variation of developed magnetically responsive silica and curcumin functionalization was scrutinized using X-ray diffraction (XRD), surface area analysis (BET), Fourier transformed infrared spectroscopy (FT-IR), Scanning electron microscope (SEM) and Transmission electron microscope (TEM). The coordination of iron oxide over silica was studied using DRS-UV spectroscopy. The magnetization property was analyzed using Vibrating Sample Magnetometry (VSM). SPIONs loaded over Q-10, SBA-16 and MSU-Foam were found to be magnetically ...

example 2

Cancer Cell Viability

[0169]Materials and Methods / Cell cultures: In this study, a human mammary adenocarcinoma cell line, MCF7, was used for in vitro testing. MCF7 cells were maintained in DMEM (Dulbecco's Modified Eagle Medium) (Gibco, life technologies) supplemented with 10% heat inactivated fetal bovine serum (HI-FBS) (Gibco, life technology), 1% Penicillin Streptomycin (100×-Gibco, life technology), and 1% MEM NEAA (MEM non-essential amino acids) (100×-Gibco, life technology). Cells were kept in a humidified incubator at 37° C. with 5% CO2. For the experimental setup, MCF7 cells were seeded on a 96-well plate at a density of 10,000 cells / well. On the next day, cells were shifted to the starve media (0.5% HI-FBS containing media) for 24 h before treatment.

[0170]Treatment: Six groups were tested: Mesocellular foam silica (group I), Fe2O3 (group II), curcumin (group III), Mesocellular foam silica+Fe2O3 (group IV), silica+curcumin (group V), and Mesocellular foam silica+Fe2O3+curcumi...

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PUM

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Abstract

Silica nanocarriers hybridized with superparamagnetic iron oxide nanoparticles (“SPIONs”) and curcumin through equilibrium or enforced adsorption technique. Methods for dual delivery of SPIONs and curcumin to a target for diagnosis or therapy, for example, for SPION-based magnetic resonance imaging or for targeted delivery of curcumin to a cell or tissue. The technique can be extend to co-precipitation of mixed metal oxide involving Ni, Mn, Co and Cu oxide. The calcination temperature can be varied from 500-900° C. The nanocombination is functionalized with chitosan, polyacrylic acid, PLGA or another agent to increase its biocompatibility in vivo.

Description

BACKGROUND OF THE INVENTION[0001]Field of the Invention[0002]The embodiments herein generally relate to the field of nanomedicine, molecular imaging, and drug delivery.[0003]Description of Related Art[0004]The “background” description provided herein is for the purpose of generally presenting the context of the disclosure. Work of the presently named inventor(s), to the extent it is described in this background section, as well as aspects of the description which may not otherwise qualify as prior art at the time of filing, are neither expressly or impliedly admitted as prior art against the present invention.[0005]Cancer Treatment Limitations. The scope of therapeutic approaches to treatment of deadly diseases such as cancer and diabetes as well as other metabolic disorders has been expanded and redefined by recent interdisciplinary research between medicine and nanotechnology (nanomedicine). In particular, the treatment of cancer poses major challenges worldwide. Numbers of cancer...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K49/04A61K49/18A61K49/08A61K47/68A61K47/69A61K31/12A61P35/00
CPCA61K49/0428A61K49/1878A61K49/08A61K47/6803B82Y5/00A61K47/6929A61K31/12A61P35/00A61K47/6883A61K47/6923
Inventor JERMY, B. RABINDRANRAVINAYAGAM, VIJAYA
Owner IMAM ABDULRAHRNAN BIN FAISAL UNIVERSITY