Cationic liposomes for gene transfer

a technology of cationic liposomes and gene transfer, which is applied in the direction of organic chemistry, chemical apparatus and processes, and material ingredients, etc., can solve the problems of varying degrees of lipid/dna treatment animals, strong inhibition of transfection efficiency, and increased toxicity of lipid/dna treated animals, so as to ensure stability in solution, good membrane fluidity, and minimal toxicity
US7002042B2Inactive Publication Date: 2006-02-21VANDERBILT UNIV
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
VANDERBILT UNIV
Publication Date
2006-02-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of and claims the benefit of, U.S. application Ser. No. 09 / 447,688, filed Nov. 23, 1999, now U.S. Pat. No. 6,656,498. U.S. application Ser. No. 09 / 447,688 claims the benefit of U.S. Provisional Application Nos. 60 / 109,950, filed Nov. 25, 1998 and 60 / 110,970, filed Dec. 4, 1998. U.S. Application Nos. 09 / 447,688, 60 / 109,950, and 60 / 110,970 are each incorporated herein by this reference in their entireties.STATEMENT OF GOVERNMENT INTEREST

[0002] This invention was made with government support under Grant Nos. NIH 5 P50 HL 19153, NIH 5 RO1 HL 45151 and NIH 5 RO1 AI 31900 awarded by the National Institutes of Health to Vanderbilt University. The U.S. Government has certain rights in the invention.FIELD OF THE INVENTION

[0003] This invention relates to synthetic cationic lipid compounds, liposome formulations and the use of such compounds via lipofection to introduce functional bioactive agents / biologically active s...

Claims

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