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Compound amino acid vitamin dispersion tablet and its preparation method

A technology of compound amino acids and vitamins, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. Improved utilization, easy portability, and wide-ranging clinical applications

Active Publication Date: 2008-01-30
无锡正东药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The compound ammonia vitamin capsules currently sold on the market is an effective preparation in this field, but because of the poor water solubility of the active ingredients in it, such as tryptophan, phenylalanine, vitamin B2, folic acid, etc., it affects the absorption. It also limits the clinical promotion and use of the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] White tablet prescription is: Isoleucine (C 6 h 13 NO 2 ) 18.0g, leucine (C 6 h 13 NO 2 ) 10.0g, lysine hydrochloride (C 6 h 14 N 2 o 2 HCl) 21.75g, phenylalanine (C 9 h 11 NO 2 ) 7.5g, threonine (C 4 h 9 NO 3 ) 4.0g, valine (C 5 h 11 NO 2 )6.0g, tryptophan (C 11 h 12 N 2 o 2 )5.0g, methionine (C 15 h 11 NO 2 S) 18.0g, arginine hydrochloride (C 6 h 14 N 4 o 2 HCl) 10.0g, glutamic acid (C 5 h 9 NO 4 ) 15.0g, glycine (C 2 h 5 NO 2 ) 25.0g, croscarmellose sodium 40g, sodium carboxymethyl starch 20g, microcrystalline cellulose 160g, sodium lauryl sulfate 6g, micropowder silica gel 6g, magnesium stearate 3g, 2-10% poly Appropriate amount of vitamin K30 ethanol solution;

[0023] Orange tablets are prescribed for: Vitamin B 1 Nitrate (C 12 h 17 ClN 4 OS·HNO 3 )7.5g, vitamin B 2 (C 17 h 20 N 4 o 6 ) 2.5g, vitamin B6 (C 8 h 11 N 30 HCl) 7.0g, vitamin E (C 31 h 52 o 3 ) 2.0g, nicotinamide (C 6 h 6 N 2 O) 15.0g, folic acid (C ...

Embodiment 2

[0030] White tablet prescription is: Isoleucine (C 6 h 13 NO 2 ) 18.0g, leucine (C 6 h 13 NO 2 ) 10.0g, lysine hydrochloride (C 6 h 14 N 2 o 2 HCl) 21.75g, phenylalanine (C 9 h 11 NO 2 ) 7.5g, threonine (C 4 h 9 NO 3 ) 4.0g, valine (C 5 h 11 NO 2 )6.0g, tryptophan (C 11 h 12 N 2 o 2 )5.0g, methionine (C 15 h 11 NO 2 S) 18.0g, arginine hydrochloride (C 6 h 14 N 4 o 2 HCl) 10.0g, glutamic acid (C 5 h 9 NO 4 ) 15.0g, glycine (C 2 h 5 NO 2 ) 25.0g, croscarmellose sodium 10g, sodium carboxymethyl starch 5g, microcrystalline cellulose 50g, sodium lauryl sulfate 2g, micropowder silica gel 2g, magnesium stearate 1g, 10% povidone Appropriate amount of K30 ethanol solution;

[0031] Orange tablets are prescribed for: Vitamin B 1 Nitrate (C 12 h 17 ClN 4 OS·HNO 3 )7.5g, vitamin B 2 (C 17 h 20 N 4 o 6 ) 2.5g, vitamin B6 (C 8 h 11 N 30 HCl) 7.0g, vitamin E (C 31 h 52 o 3 ) 2.0g, nicotinamide (C 6 h 6 N 2 O) 15.0g, folic acid (C 19 h 19...

Embodiment 3

[0038] White tablet prescription is: Isoleucine (C 6 h 13 NO 2 ) 18.0g, leucine (C6 h 13 NO 2 ) 10.0g, lysine hydrochloride (C 6 h 14 N 2 o 2 HCl) 21.75g, phenylalanine (C 9 h 11 NO 2 ) 7.5g, threonine (C 4 h 9 NO 3 ) 4.0g, valine (C 5 h 11 NO 2 )6.0g, tryptophan (C 11 h 12 N 2 o 2 )5.0g, methionine (C 15 h 11 NO 2 S) 18.0g, arginine hydrochloride (C 6 h 14 N 4 o 2 HCl) 10.0g, glutamic acid (C 5 h 9 NO 4 ) 15.0g, glycine (C 2 h 5 NO 2 ) 25.0g, croscarmellose sodium 80g, sodium carboxymethyl starch 40g, microcrystalline cellulose 300g, sodium lauryl sulfate 12g, micropowder silica gel 12g, magnesium stearate 6g, 10% povidone Appropriate amount of K30 ethanol solution;

[0039] Orange tablets are prescribed for: Vitamin B 1 Nitrate (C 12 h 17 ClN 4 OS·HNO 3 )7.5g, vitamin B 2 (C 17 h 20 N 4 o 6 ) 2.5g, vitamin B6 (C 8 h 11 N 30 HCl) 7.0g, vitamin E (C 30 h 52 o 3 ) 2.0g, nicotinamide (C 6 h 6 N 2 O) 15.0g, folic acid (C 19 h ...

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PUM

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Abstract

A dispersing tablet of compound amino acid-vitamin for treating throat disease and hypoproteinemia contains 11 amino acids including L-isoleucine, L-leucine, L-lysine hydrochloride, etc, 6 vitamins including VB1 nitrate, VB2, VB6, etc, cross-linked carboxymethyl cellulose sodium carboxymethyl starch sodium and microcrystalline cellulose. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a compound amino acid vitamin dispersible tablet for auxiliary treatment of hypoproteinemia and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Amino acids are the basic units that make up protein and are also very important nutrients. In the body, in addition to being used to synthesize tissue proteins, amino acids are deaminated to generate α-keto acids, which can be further oxidized for energy and converted into sugars and fats. In addition, amino acids can also serve as substrates for glucose and nitrogen carriers, and participate in the regulation of enzyme activity and ion channels. [0003] The protein in food must be digested by the gastrointestinal tract and decomposed into amino acids before it can be absorbed and utilized by the human body. The human body's need for protein is actually the need for amino acids. Only when the absorbed amino acids mee...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/405A61K31/198A61K31/355A61K31/51A61K9/20A61K47/36A61P3/02
Inventor 刘毅琳
Owner 无锡正东药业有限公司
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