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Framberry leaf extract effective part and its composition and uses

A technology of effective parts and leaf extracts, applied in the field of effective parts of plant extracts and compositions thereof, and can solve problems such as adverse effects

Inactive Publication Date: 2008-03-12
BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current oral hypoglycemic drugs all have more or less adverse effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1 Preparation of effective fraction of raspberry leaf extract

[0043] The raspberry leaves are dried in the shade in a ventilated environment, and are crushed into about 1cm. Weigh 10 kg of dried and pulverized raspberry leaves, extract three times at 80°C with 80L, 60L and 40L of 60(v / v)% ethanol respectively, extract for 2 hours, 2 hours and 1 hour each time, filter and combine the extraction filtrates , after recovering ethanol with a continuous vacuum thin-film evaporator and a rotary evaporator, a dry paste was obtained for future use.

[0044] Suspend 1.5Kg of dry paste in 10L of distilled water, extract with 8 times the volume of petroleum ether, ethyl acetate, and water-saturated n-butanol in sequence, and recover the solvent in the extract respectively to obtain its petroleum ether (RP) fraction. , ethyl acetate (RE) site, n-butanol (RB) site and water (RW) site.

Embodiment 2

[0045] Example 2 Coated Tablets Containing n-Butanol (RB) Parts Preparation Tablet Composition:

[0046] 32 grams of RB; 5 grams of dextrin; 8ml of 95v / v% ethanol; 2 grams of talcum powder; 1 gram of magnesium stearate;

[0047] The materials of the above composition are prepared into plain tablets according to conventional methods for future use. Coated tablets containing n-butanol moieties were obtained by spraying the following coating suspension and coating mixture 3 on the obtained plain tablets.

[0048] Preparation:

[0049] (1) Obtain the RB position according to the method of Example 1;

[0050] (2) Take 32 grams of RB, grind it into fine powder, add 5 grams of dextrin, mix well and pass through a 100-mesh sieve;

[0051] (3) Add 8ml of ethanol with a concentration of 95v / v% to the mixture of step (2) to moisten, pass through a 40-mesh sieve to make wet granules, and dry the granules in an oven at 60°C until the moisture content is 5w / w%. , sizing with a 40 mesh s...

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PUM

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Abstract

The present invention relates to raspberry extract and its composition and their application in preparing medicine for diabetes. The solvent extracted raspberry extract is divided into four parts, including RE, RB, RW and RP, where RB and RW are effective parts. The effective parts RB and RW may be prepared alone or in combination or via adding certain amount of ginseng, astragalus root, ophiopogon root, schisandra, manyprickle acanthopanax root and / or rhodiola root and pharmaceutically acceptable carrier, into tablet, capsule, granule or other preparation forms. Mouse and rat diabetes mold test shows that RB and / or RW have obvious hypoglycemic effect and remitting the syndromes of diabetes. The hypoglycemic mechanism of RB and RW maybe comes from their insulin sensitizing effect or influence on sugar absorption.

Description

technical field [0001] The present invention relates to an effective part of a plant extract and its composition, especially the effective part of a raspberry leaf extract and its composition and its application in the preparation of medicines for preventing and treating diabetes. Background technique [0002] The incidence of diabetes in countries around the world is on the rise. According to WHO reports: In recent years, there are about 160 million diabetic patients in the world. The incidence of diabetes in my country is also increasing. According to statistics, there are 40 million diabetics in my country (Huang Qiuyun et al., Research Progress and Review of Diabetes Drugs, Strait Pharmacy, 2002: 14 (2) 56-57). Among diabetics, 90% of them are non-insulin-dependent diabetics, namely type II diabetics. These patients mainly use oral hypoglycemic drugs to control blood sugar concentration. But the current oral hypoglycemic drugs all have more or less adverse effects. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61K9/00A61P3/10
Inventor 许奕华张玉平陈梅香
Owner BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES