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Composite collagen eye drops

A collagen and protoprotein technology, applied in the field of medical drugs, can solve the problems of short effective time of drug properties, poor drug penetration effect, easy generation of drug resistance, etc., and achieve the effects of prolonging the effective time, reducing visual fatigue, and preventing dry eye disease.

Active Publication Date: 2008-04-16
GUANGZHOU TRAUER BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Taking collagen as a raw material to add an appropriate amount of antibiotic ofloxacin to make eye drops is less used in ophthalmic medical treatment. Most of the eye drops containing antibiotics in the prior art are chemical synthetics, lack biological activity, and After the eye drops combined with chemical synthetic products and antibiotics are instilled into the eyes, the drug penetration effect is poor, the drug effect is effective for a short time, and long-term use is easy to produce drug resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] A kind of composite collagen eye drop, its component and the weight ratio of each component are: in every 100ml composite collagen eye drop, collagen protein content is 50mg; Antibiotic is ofloxacin, and this ofloxacin The content is 300 mg, and the rest is isotonic solution, which is 5% glucose solution.

[0012] This composite collagen eye drops has been tested as follows:

[0013] After more than 10 months of application, 14 cases (23 eyes) of patients with corneal diseases were treated with compound collagen eye drops. Among them: 9 cases of binocular (18 eyes), 5 cases of monocular (5 eyes); 8 cases of male (14 eyes), 6 cases of female (9 eyes); aged from 12 to 70 years old. Among them, there were 3 cases of corneal surgery (5 eyes), 3 cases of corneal injury (5 eyes), 3 cases of punctate keratitis (5 eyes), 2 cases of corneal ulcer (3 eyes), and 1 case of dry eye disease (2 eyes). eye), thermal injury in 1 case (1 eye), eye chemical injury (mild) in 1 case (2 ey...

Embodiment 2

[0016] A kind of composite collagen eye drop, its component and the weight ratio of each component are: in every 100ml composite collagen eye drop, collagen protein content is 100mg; Antibiotic is ofloxacin, and this ofloxacin The content is 350 mg, and the rest is isotonic solution, which is 5% glucose solution.

[0017] This composite collagen eye drops has been tested as follows:

[0018] After more than 10 months of application, 14 cases (23 eyes) of patients with corneal diseases were treated with compound collagen eye drops. Among them: 9 cases of binocular (18 eyes), 5 cases of monocular (5 eyes); 8 cases of male (14 eyes), 6 cases of female (9 eyes), aged 12 to 70 years old. Among them, there were 3 cases of corneal surgery (5 eyes), 3 cases of corneal injury (5 eyes), 3 cases of punctate keratitis (5 eyes), 2 cases of corneal ulcer (3 eyes), and 1 case of dry eye disease (2 eyes). eye), thermal injury in 1 case (1 eye), eye chemical injury (mild) in 1 case (2 eyes)....

Embodiment 3

[0021] A kind of composite collagen eye drop, its component and the weight ratio of each component are: in every 100ml composite collagen eye drop, collagen protein content is 150mg; Antibiotic is ofloxacin, and this ofloxacin The content is 400 mg, and the rest is isotonic solution, which is 5% glucose solution.

[0022] This composite collagen eye drops has been tested as follows:

[0023] After more than 10 months of application, 14 cases (23 eyes) of patients with corneal diseases were treated with compound collagen eye drops. Among them: 9 cases of binocular (18 eyes), 5 cases of monocular (5 eyes); 8 cases of male (14 eyes), 6 cases of female (9 eyes); aged from 12 to 70 years old. Among them, there were 3 cases of corneal surgery (5 eyes), 3 cases of corneal injury (5 eyes), 3 cases of punctate keratitis (5 eyes), 2 cases of corneal ulcer (3 eyes), and 1 case of dry eye disease (2 eyes). eye), thermal injury in 1 case (1 eye), eye chemical injury (mild) in 1 case (2 e...

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PUM

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Abstract

The invention relates to a kind of compound collagen protein gutta, which is the mixture of collagen protein and antibiotics. For every 100ml compound collagen gutta, there is 10-500mg collagen protein which is extracted from the tendon, 100-600mg antibiotics which include one or two kinds of the following antibiotics: ofloxacin, alficetin, tenebrimycin, while the rest is the iso-osmia, which is 5% amylaceum solution. The product has three main functions: resist bacteria and inflammation; help to keep the eyeball moist, promote the agglutination and relieve the asthenopia; be used in the treatment of the damage to the cornea, keratohelcosis, keratitis punctata, slight chemical injury to cornea as well as the thermal damage to the cornea; prevent the ophthalmia and relieve the asthenopia; prevent the cohesive property of the collagen from being diluted so as to extend the effective time of the gutta; resist the bacteria as well as promote the agglutination.

Description

technical field [0001] The present invention relates to medical drugs. Background technique [0002] Taking collagen as a raw material to add an appropriate amount of antibiotic ofloxacin to make eye drops is less used in ophthalmic medical treatment. Most of the eye drops containing antibiotics in the prior art are chemical synthetics, lack biological activity, and After the eye drops combined with chemical synthetics and antibiotics are instilled into the eyes, the penetration effect of the drug property is poor, the effective time of the drug property is short, and drug resistance is easy to develop after long-term use. In order to further improve the curative effect and enhance the biocompatibility, it is necessary to develop new eye drop varieties. Contents of the invention [0003] The object of the present invention is to provide a composite collagen eye drop, which not only has antibacterial and anti-inflammatory effects, but also has the effects of keeping eyebal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61K45/06A61P27/02
Inventor 佟刚
Owner GUANGZHOU TRAUER BIOTECH
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