Method for preparing carbon nano-tube/poly L-cysteine composite modified glassy carbon electrode

A technology of cysteine ​​and glassy carbon electrodes, which is applied in the direction of material electrochemical variables, can solve the problems of cumbersome electrode preparation methods, expensive electrode modification materials, and limited current peak resolution, and achieve a firm electrode modification layer and low cost , little effect

Inactive Publication Date: 2008-08-13
YANGZHOU UNIV
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Problems solved by technology

However, the current peak resolution of the three existing methods is limited, the sensitivity is not high, the electrode preparation method is cumbersome, the electrode modification materials are expensive, not easy to obtain, and the biocompatibility is not good
So far, there has been no literature report on the modification of multi-walled carbon nanotubes and L-cysteine ​​to glassy carbon electrodes to make composite modified electrodes for the simultaneous determination of uric acid, dopamine, and ascorbic acid.

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  • Method for preparing carbon nano-tube/poly L-cysteine composite modified glassy carbon electrode
  • Method for preparing carbon nano-tube/poly L-cysteine composite modified glassy carbon electrode
  • Method for preparing carbon nano-tube/poly L-cysteine composite modified glassy carbon electrode

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Embodiment Construction

[0013] For the pretreatment of bare glassy carbon electrodes, use 0.3μm and 0.05μm ultrafine Al 2 O 3 The suspension was polished on silk, then ultrasonically cleaned in double distilled water for five minutes, and finally dried with high-purity nitrogen for use.

[0014] Purification of carbon nanotubes, placing 10 mg of multi-walled carbon nanotubes (MWNCTs) in 40 mL of concentrated HNO 3 Stir and reflux for 12 hours and let it stand. When the carbon nanotubes have settled completely, the supernatant liquid is decanted, and the carbon nanotube precipitation is washed with secondary water several times until the supernatant liquid shows a neutral pH. The carbon nanotube precipitation was vacuum dried for 24h.

[0015] Preparation of carbon nanotube modified electrode. Add 1 mg of multi-walled carbon nanotubes after acidification to 10 mL of N,N-dimethylformamide (DMF), and ultrasonically disperse for 30 minutes to obtain a uniform black solution (concentration of 0.1 mg). ·ML -1 ...

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Abstract

The invention relates to a manufacture method for carbon nm tube / poly L-cysteine compound modification glass carbon electrode. The process includes the following steps: purifying the multi-wall carbon nm tube, separating into N, N-dimethyl formamide solution, dropping the solution onto the surface of glass carbon electrode, drying under infrared light, locating the electrode into dilute hydrochloric acid containing L-cysteine to take electric polymerizing; taking out the electrode compounding L-cysteine to wash and gain carbon nm tube / poly L-cysteine compound modification glass carbon electrode. The method is simple, and low cost. The product has high reliability and good repeatability. It has long useful life and could be used in electrochemistry rapidly testing for uric acid and ascorbic acid in blood serum.

Description

Technical field [0001] The invention relates to a preparation method of a carbon nanotube / poly-L-cysteine ​​composite modified glassy carbon electrode for realizing simultaneous and rapid determination of uric acid, dopamine and ascorbic acid in serum. Background technique [0002] Uric acid is the main product of purine metabolism. Abnormal uric acid concentration in human body fluids can cause many diseases, such as gout and hyperuricemia. Excessive blood uric acid concentration can cause renal failure and cardiovascular disease. Therefore, the rapid and accurate determination of the concentration of uric acid in body fluids or blood is of great significance in biochemical and clinical diagnosis. Nowadays, enzyme-linked colorimetry is often used in clinics. Its advantage is high selectivity, but it is affected by enzyme activity, it has poor stability, expensive equipment, and low sensitivity. The electrochemical determination method has attracted widespread attention due to it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30
Inventor 王赪胤邵晓秋刘清秀杨功俊胡效亚
Owner YANGZHOU UNIV
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