Preparation method of sodium iron chlorophyllin-ethyl cellulose microcapsule

A technology of ethyl cellulose and sodium iron chlorophyllide, which is applied in the field of preparation of medicinal and food pigments, can solve the problems that have not yet been seen in microcapsules of sodium iron chlorophyllide, achieve excellent physical and chemical stability, and enhance stability Sexual, slightly toxic effects

Inactive Publication Date: 2009-02-18
NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Up to now, there is no research report on iron sodium chlorophyllin microcapsules, especially the preparation of iron sodium chlorophyllin microcapsules with ethyl cellulose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] The present invention will be further described below in conjunction with the examples.

[0010] Main instruments: AEL-160 electronic balance; HH-S digital display constant temperature water bath; booster electric mixer; centrifuge; drug dissolution apparatus; KYKY2800 scanning electron microscope with a resolution of 4.5nm; laser particle size analyzer; .

[0011] Reagents and raw materials: carbon tetrachloride, petroleum ether, ethyl cellulose; sodium iron chlorophyllin.

[0012] specific steps

[0013] Take sodium iron chlorophyllin, add it to the carbon tetrachloride solution solvent of 2% ethyl cellulose, place it in a HH-S digital display constant temperature water bath at a constant temperature of 39 to 41°C, stir evenly at a speed of 350r / min, and prepare into iron sodium chlorophyllinate suspension; the iron sodium chlorophyllinate suspension is added to petroleum ether non-solvent while stirring (according to the weight ratio of selection), and the booster ...

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Abstract

A preparation method of sodium iron chlorophyllin-ethyl cellulose microcapsule belongs to preparation field of medicinal and edible pigment. the method with sodium iron chlorophyllin as contents and ethyl cellulose as capsule comprises adding sodium iron chlorophyllin into 2% ethyl cellulose carbon tetrachloride solution, stirring in aqueous thermostat, making into suspensoid solution of sodium iron chlorophyllin, adding to non-solvent of petroleum ether, stirring for 1h, centrifugalizing for 20min, washing with petroleum ether for several time, removing supernatant, paving on the surface of glass plate, and drying in drying oven to obtain the final product. The microcapsule with EC as capsule materials has the advantages of stable property, little toxicity. Microcapsule prepared with auxiliary materials at a certain proportion has slow release, which can maintain effective blood concentration for a long time, and guarantee the therapeutic effect of the drugs.

Description

technical field [0001] The invention relates to a preparation method of sodium iron chlorophyllin-ethyl cellulose microcapsules, belonging to the field of preparation methods of medicinal and food pigments. Background technique [0002] Sodium iron chlorophyllin (including iron (II) chlorophyllin and iron (III) chlorophyllin) is easily soluble in water or dilute alcohol solution, but insoluble in oils and fats. After research and testing, the sodium iron chlorophyllinate solution is stable against indoor light, but its stability against outdoor natural light is not ideal. In addition to being a good food coloring, sodium iron chlorophyllin can also be used as an iron fortifier in medicine. Shengxuening tablets made of sodium iron chlorophyllin have been successfully used in the treatment of iron deficiency anemia. This is the only dosage form of iron chlorophyllin sodium salt in China. Utilizing the characteristics of microcapsules, the further microencapsulation treatment...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/58A61K31/409A61K47/38A61P7/06A61P3/02A23L5/40
Inventor 刘淑萍王丽芸闫路省
Owner NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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