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Tinidazole vaginal soft capsule and its preparing method

A technology of tinidazole and soft capsules, applied in the field of tinidazole vaginal soft capsules and preparation thereof, can solve problems such as unseen

Inactive Publication Date: 2009-06-10
XIAN ZHENGQING MEDICINE TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no external vaginal soft capsule made from tinidazole

Method used

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  • Tinidazole vaginal soft capsule and its preparing method
  • Tinidazole vaginal soft capsule and its preparing method
  • Tinidazole vaginal soft capsule and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Component Quantity (g / granule)

[0086] Liquid medicine: Tinidazole 0.15

[0087] White Vaseline 0.82

[0088] Liquid paraffin 1.22

[0089] Glue: Gelatin 0.350

[0090] Glycerin 0.140

[0091] Distilled water 0.350

[0092] Titanium dioxide 0.01

[0093] Ethyl p-hydroxybenzoate 0.0007

[0094] Preparation:

[0095] Heat white petrolatum and liquid paraffin and fully stir, then cool naturally, add tinidazole fine powder, stir and pass through a colloid mill to mix evenly, set aside.

[0096] Soak and swell the gelatin in distilled water in the glue tank, add glycerin, titanium dioxide, and ethyl p-hydroxybenzoate, heat and stir to make it melt into uniform gelatin, remove the bubbles in the glue under reduced pressure, and then concentrate to Measure the viscosity at 70-80°C to be 28,000-32,000 millipoise, put it into a temperature-adjustable rubber stabilization barrel, pour the prepared medicinal solution into the medi...

Embodiment 2

[0098] Component Quantity (g / granule)

[0099] Liquid medicine: Tinidazole 0.3

[0100] Vaseline 1.2

[0101] Liquid paraffin 1.5

[0102] Glue: Gelatin 0.5

[0103] Glycerin 0.27

[0104]Distilled water 0.5

[0105] Titanium dioxide 0.05

[0106] Methylparaben 0.003

[0107] Preparation:

[0108] Heat white petrolatum and liquid paraffin and fully stir, then cool naturally, add tinidazole fine powder, stir and pass through a colloid mill to mix evenly, set aside.

[0109] Soak and swell the gelatin in distilled water in the glue tank, add glycerin, titanium dioxide, and methyl p-hydroxybenzoate, heat and stir to make it melt into uniform gelatin, remove the bubbles in the glue under reduced pressure, and then concentrate to Measure the viscosity at 70-80°C to be 28,000-32,000 millipoise, put it into a temperature-adjustable rubber stabilization barrel, pour the prepared medicinal solution into the medicinal liquid bucket, press the ...

Embodiment 3

[0111] Component Quantity (g / granule)

[0112] Liquid medicine: Tinidazole 0.05

[0113] Vaseline 0.4

[0114] Liquid paraffin 0.4

[0115] Glue: Gelatin 0.2

[0116] Glycerin 0.1

[0117] Distilled water 0.2

[0118] Titanium dioxide 0.001

[0119] Clove oil 0.0001

[0120] Preparation:

[0121] Heat white petrolatum and liquid paraffin and fully stir, then cool naturally, add tinidazole fine powder, stir and pass through a colloid mill to mix evenly, set aside.

[0122] Soak and swell the gelatin in distilled water first in the glue tank, add glycerin, titanium dioxide, and clove oil, heat and stir to make it melt into uniform gelatin, remove the bubbles in the glue under reduced pressure, and then concentrate to 70-80 The measured viscosity at ℃ is 28000-32000 millipoise, put it into a temperature-adjustable plastic barrel, pour the prepared medicine solution into the medicine solution bucket, press the soft capsule with a m...

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Abstract

The present invention relates to soft tinidazole capsule for vagina and its production process. Each of soft tinidazole capsules contains tinidazole in 50-300 mg and medicinal supplementary material vaseline and paraffin, and the capsule shell contains gelatin in 10 weight portions and glycerin in 4.0-5.5 weight portions. The production process includes the steps of dissolving gelatin in water and adding glycerin and proper amount of preservative, vacuum deairing, mixing tinidazole and medicinal supplementary material, and pressing into soft capsule. Compared with available tinidazole preparation forms, the soft tinidazole capsule has the advantages of stable quality, convenient carrying and administration, and fast leaching of the effective components.

Description

technical field [0001] The invention relates to a tinidazole vaginal soft capsule and a preparation method thereof. Background technique [0002] Trichomonal vaginitis is one of the sexually transmitted diseases caused by the flagellate protozoa Trichomonas vaginalis. The disease is distributed in all parts of the world, in various climates and in different populations, and the female incidence rate is 10%-25%. Often coexist with other sexually transmitted diseases, such as 50% of gonorrhea patients with trichomoniasis. Trichomoniasis can also be transmitted indirectly through bathrooms, toilets, underwear and various sanitary utensils. Newborns can acquire latent infection from the birth canal of sick mothers, and children can be indirectly infected through contaminated clothing, toys in kindergartens, and contaminated hands of staff. The disease may be complicated by trichomonas urethritis, cystitis, and pyelitis. Because trichomonas can swallow sperm, it can cause infe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4164A61K9/48A61P15/02
Inventor 胡笑歌
Owner XIAN ZHENGQING MEDICINE TECH DEV
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