Therapeutic vaccine for Myostatin specific antibody and its preparation method
A therapeutic vaccine and specific technology, applied in the field of medicine and biology, can solve the problems of immaturity, weak immune response, and danger of foreign aid DNA integration, and achieve the effect of improving immunogenicity, skeletal muscle quality and strength.
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[0104] The invention artificially synthesizes the gene sequence of the myostatin C-terminal region (133 amino acids) by using the method of synthesizing genes, and constructs two therapeutic vaccines for myostatin, a gene vaccine and a protein vaccine. In order to break the immune tolerance of the myostatin vaccine and enhance the immunogenicity of the vaccine, a universal Th cell epitope TT derived from tetanus toxin and capable of activating Th cells was inserted into the N-end of the myostatin protein vaccine and gene vaccine when constructing the vaccine. 830-844 To enhance the immune effect of the two therapeutic vaccines of myostatin. Taking advantage of the effect of antigen expression vector on antigen immunogenicity, the immunogenicity of gene peptidin was selected when constructing genetic vaccine. Immunization of healthy adult BALB / c mice can induce specific vaccine-specific plasmid pVAC1-cms for human myostatin molecules. The plasmid pQE30 fused to express 6His is us...
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