Near infrared microbial elimination laser system
A technology of laser system and subsystem, applied in the field of off-site and on-site sterilization, can solve problems such as narrow treatment window
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Embodiment I
[0058] The prior art literature (Neuman, Biophysical Journal, Vol.77, November 1999, infra) reported that 870nm and 930nm radiation from a tunable Ti:sapphire laser caused a 7-fold increase in E. coli during confocal microscopy. mortality rate. A careful study of this information by the inventors of the present invention has led to the following conclusions. On the face of it, the power density (brightness)—besides the 870nm and 930nm wavelengths—is the most important parameter for inducing the above-mentioned toxic singlet oxygen reaction. This can be calculated using the following formula: Power Density (W / cm 2 ) = total power (W) X spot size (cm 2 ). Using this relationship, it was calculated that with at least 100 mW and adjustments to the spot size, the necessary bacterial density could be achieved. It is believed that the toxic singlet oxygen reaction occurs according to the power density curve. Adjustments can be made by increasing the power (always below that whic...
Embodiment II
[0060] The unique germicidal power of 870nm and 930nm radiation may be illustrated by the following equation, which takes into account the wave nature of light, the wavelength-based energy of each photon, and the effect this energy has on the cell: E=hf, where E = energy, h = Plank constant, f = speed of light / wavelength. E=hf truly describes the momentum of the photon. In other words, the momentum of a photon is directly related to its energy. This means that the shorter the wavelength, the greater the photon's momentum (energy). Consider the following.
[0061] UV wavelength
[0062] 1) 193nm ArF laser produces UV-C of 6.4 electron volts / photon (EV / photon)
[0063] 2) 308nm XeCl laser produces UV-A at 4.0EV / photon.
[0064] Visible light wavelength
[0065] 1) 514nm Ar laser produces 2.4EV / photon
[0066] 2) 633nm He-Ne laser produces 2.0EV / photon
[0067] infrared wavelength
[0068] 1) 800nm diode laser produces 1.6EV / photon
[0069] 2) 2940nm Er:Yag lase...
Embodiment III
[0073] It is well known that: (1) ultraviolet light and ultraviolet lasers are more energetic than visible or infrared, and they "inherently" have the property of inducing mutations in organisms; (2) ultraviolet (non-ionizing) radiation greater than six EV / photon (eg UV ArF) can excite electrons in biomolecules (such as DNA) to ionized states; (3) less than six EV / photons (UV-A, UV-B, visible and infrared) can only excite biomolecules electrons to more High electronic or vibrational states, rather than ionized states, because photons carry much less energy; (4) UV-B and UV-A can cause considerable crosslinking damage without ionization, again because they are in The extra electron volts carried at this non-ionizing UV wavelength.
[0074] It is these higher energy ionized states induced by certain higher energy UV photons (UV-C) after absorption by biomolecules that lead to pyrimidine dimers in DNA.
[0075] Regardless of the energy density, the energies at 870nm and 930nm on...
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