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Separately packed fatty milk, amino acid and glucose injection composition and the prepn process

A glucose injection and long-chain fat emulsion technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of construction of aseptic preparation rooms, high maintenance costs, obstacles to the promotion of mixed infusion methods, and easy Capillary blockage and other problems can be avoided to avoid microbial and particle contamination of the product, scientific and reasonable clinical use, and the effect of reducing the heat source reaction of infusion

Inactive Publication Date: 2007-08-22
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even with aseptic operating conditions, the probability of contaminating microorganisms is more than one in a thousand
In addition, the construction and maintenance costs of aseptic preparation rooms are quite high, which can be afforded by non-small and medium-sized hospitals and economically underdeveloped areas, which largely hinders the promotion of mixed infusion methods
Another disadvantage of this mixing method is that multiple punctures of the rubber plug will inevitably produce a large number of rubber plug particles, which will easily block the capillaries after entering the blood, causing microcirculation embolism

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Step one, bag making.

[0076] Take the plastic film for the inner bag, press it on the bag making hot press and connect the filling port. Take the plastic film for the outer bag, press it on the bag making heat press, and leave one side open.

[0077] Step two, dosing. Medium / long-chain fat emulsion injection, compound amino acid injection and glucose injection were prepared on different preparation equipment.

[0078] a. Preparation of Medium / Long Chain Fat Emulsion Injection

[0079] Take 150 grams of purified soybean oil, 50 grams of medium-chain triglycerides, 13 grams of refined egg yolk lecithin, 0.4 grams of sodium oleate, 30 grams of anhydrous glycerin, appropriate amount of sodium hydroxide, and 750 grams of water for injection.

[0080] The purified soybean oil and medium chain triglycerides are heated to about 60°C, which is the oil phase.

[0081] Add refined egg yolk lecithin, sodium oleate and anhydrous glycerin to 750 grams of water for injection, st...

Embodiment 2

[0096] Step one, bag making.

[0097] Take the plastic film for the inner bag, press it on the bag making hot press and connect the filling port. Take the plastic film for the outer bag, press it on the bag making heat press, and leave one side open.

[0098] Step two, dosing. Medium / long-chain fat emulsion injection, compound amino acid injection and glucose injection were prepared on different preparation equipment.

[0099] a. Preparation of Medium / Long Chain Fat Emulsion Injection

[0100] Take 100 grams of purified soybean oil, 100 grams of medium-chain triglycerides, 12 grams of refined egg yolk lecithin, 0.3 grams of sodium oleate, 25 grams of anhydrous glycerin, appropriate amount of sodium hydroxide, and 750 grams of water for injection.

[0101] The purified soybean oil and medium chain triglycerides are heated to about 60°C, which is the oil phase.

[0102] Add refined egg yolk lecithin, sodium oleate and anhydrous glycerin to 750 grams of water for injection, s...

Embodiment 3

[0113] Step one, bag making.

[0114] Take the plastic film for the inner bag, press it on the bag making hot press and connect the filling port. Take the plastic film for the outer bag, press it on the bag making heat press, and leave one side open.

[0115] Step two, dosing. Medium / long-chain fat emulsion injection, compound amino acid injection and glucose injection were prepared on different preparation equipment.

[0116] a. Preparation of Medium / Long Chain Fat Emulsion Injection

[0117] Take 50 grams of purified soybean oil, 150 grams of medium-chain triglycerides, 11 grams of refined egg yolk lecithin, 0.2 grams of sodium oleate, 20 grams of anhydrous glycerin, appropriate amount of sodium hydroxide, and 750 grams of water for injection.

[0118] The purified soybean oil and medium chain triglycerides are heated to about 60°C, which is the oil phase.

[0119] Add refined egg yolk lecithin, sodium oleate and anhydrous glycerin to 750 grams of water for injection, stir...

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Abstract

The present invention is one kind of three-cavity packed injection composition, and has medium / long chain fatty milk injection, compound amino acid injection and glucose injection packed separately in three diaphragm separated cavities. Before intravenous infusion, the medium / long chain fatty milk injection, the compound amino acid injection and the glucose injection are squeezed out and mixed in common operation condition. The injection composition can be used to patient for meeting the requirement in protein and saccharide.

Description

technical field [0001] The invention discloses a composition of medium / long-chain fat emulsion, amino acid and glucose injection packaged independently in a three-cavity bag and a preparation method of the injection composition, wherein the main component of the medium / long-chain fat emulsion injection is For purified soybean oil and medium chain triglycerides. Background technique [0002] Fat, protein and sugar are the three types of basic nutrients that the human body needs the most. When the human gastrointestinal tract is incomplete or unable to absorb enough of the above nutrients, it must be provided in the form of intravenous infusion. Therefore, fat emulsion injection, compound amino acid injection and glucose injection are widely used clinically to provide fat, protein and sugar respectively, which is the so-called parenteral nutrition. From the perspective of nutrient metabolism mechanism, the utilization of these three nutrients is interdependent. Physiological...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/197A61K31/22A61K31/7004A61P3/02
Inventor 马涛
Owner 费森尤斯卡比华瑞制药有限公司
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