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Separately packed structural fatty milk, aminoacid and glucose injection composition and the prepn process

A technology of glucose injection and fat emulsion, which is applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as contamination of microorganisms, hindering the promotion of mixed infusion methods, construction of aseptic preparation rooms, and high maintenance costs

Active Publication Date: 2007-08-22
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even with aseptic operating conditions, the probability of contaminating microorganisms is more than one in a thousand
In addition, the construction and maintenance costs of aseptic preparation rooms are quite high, which can be afforded by non-small and medium-sized hospitals and economically underdeveloped areas, which largely hinders the promotion of mixed infusion methods
Another disadvantage of this mixing method is that multiple punctures of the rubber plug will inevitably produce a large number of rubber plug particles, which will easily block the capillaries after entering the blood, causing microcirculation embolism

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Step one, bag making.

[0095] Take the plastic film for the inner bag, press it on the bag making hot press and connect the filling port. Take the plastic film for the outer bag, press it on the bag making heat press, and leave one side open.

[0096] Step two, dosing. The structured fat emulsion injection, compound amino acid injection and glucose injection were prepared on different preparation equipment.

[0097] a. Preparation of structured fat emulsion injection

[0098] Take 250 grams of structural triglycerides, 13 grams of refined egg yolk lecithin, 24 grams of anhydrous glycerin, sodium hydroxide: appropriate amount, water for injection: 750 grams.

[0099] Heat the structural triglyceride to about 80°C, and add refined egg yolk lecithin under continuous stirring, which is the oil phase.

[0100] Add anhydrous glycerin to 750 grams of water for injection, stir to dissolve, and this is the water phase.

[0101] Slowly add the oil phase to the vigorously st...

Embodiment 2

[0115] Step one, bag making.

[0116] Take the plastic film for the inner bag, press it on the bag making hot press and connect the filling port. Take the plastic film for the outer bag, press it on the bag making heat press, and leave one side open.

[0117] Step two, dosing. The structured fat emulsion injection, compound amino acid injection and glucose injection were prepared on different preparation equipment.

[0118] a. Preparation of structured fat emulsion injection

[0119] Take 200 grams of structural triglycerides, 12 grams of refined egg yolk lecithin, 22 grams of anhydrous glycerin, sodium hydroxide: appropriate amount, water for injection: 750 grams.

[0120] Heat the structural triglyceride to about 80°C, and add refined egg yolk lecithin under continuous stirring, which is the oil phase.

[0121] Add anhydrous glycerin to 750 grams of water for injection, stir to dissolve, and this is the water phase.

[0122] Slowly add the oil phase to the vigorously st...

Embodiment 3

[0132] Step one, bag making.

[0133] Take the plastic film for the inner bag, press it on the bag making hot press and connect the filling port. Take the plastic film for the outer bag, press it on the bag making heat press, and leave one side open.

[0134] Step two, dosing. The structured fat emulsion injection, compound amino acid injection and glucose injection were prepared on different preparation equipment.

[0135] a. Preparation of structured fat emulsion injection

[0136] Take 150 grams of structural triglycerides, 11 grams of refined egg yolk lecithin, 20 grams of anhydrous glycerin, sodium hydroxide: appropriate amount, water for injection: 750 grams.

[0137] Heat the structural triglyceride to about 80°C, and add refined egg yolk lecithin under continuous stirring, which is the oil phase.

[0138] Add anhydrous glycerin to 750 grams of water for injection, stir to dissolve, and this is the water phase.

[0139] Slowly add the oil phase to the vigorously st...

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Abstract

The present invention is one kind of three-cavity packed injection composition, and has structural fatty milk injection, compound amino acid injection and glucose injection packed separately in three diaphragm separated cavities. Before intravenous infusion, the structural fatty milk injection, the compound amino acid injection and the glucose injection are squeezed out and mixed in common operation condition. The injection composition can be used to patient for meeting the requirement in protein and saccharide.

Description

technical field [0001] The invention discloses a three-cavity bag independently packaged fat emulsion, amino acid and glucose injection composition, and discloses a preparation method of the injection, wherein the main component of the structured fat emulsion is structured triglyceride. Background technique [0002] Fat, protein and sugar are the three types of basic nutrients that the human body needs the most. When the human gastrointestinal tract is incomplete or unable to absorb enough of the above nutrients, it must be provided in the form of intravenous infusion. Therefore, fat emulsion injection, compound amino acid injection and glucose injection are widely used clinically to provide fat, protein and sugar respectively, which is the so-called parenteral nutrition. From the perspective of nutrient metabolism mechanism, the utilization of these three nutrients is interdependent. Physiologically speaking, when the human body takes in food, it takes in fat, protein and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/197A61K31/22A61K31/7004A61P3/02
Inventor 马涛
Owner 费森尤斯卡比华瑞制药有限公司
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