Cream for treating alopecia and its prepn

A cream, a hair loss technology, applied in the field of topical medicines for the treatment of hair loss, can solve the problems of insecurity, limited use, short residence time at the treatment site and the like

Inactive Publication Date: 2007-08-22
AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, find in clinical application process, because this medicine is with ethanol as solvent, stay time in treatment part is short, needs to increase administr...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Embodiments of the present invention: 20 grams of minoxidil, 100 grams of stearic acid, 50 grams of glyceryl monostearate, 50 grams of white petrolatum, 150 grams of liquid paraffin, 150 grams of glycerin, 2 ml of triethanolamine, lauryl 1.6 grams of sodium sulfate, 1 gram of ethylparaben, 2.5 grams of sodium thiosulfate, 2.1 grams of disodium edetate, 20 milliliters of propylene glycol, 0.9 grams of essence, distilled water was added to the rest, and the total amount was added to 1000 grams.

[0020] Weigh stearic acid, glyceryl monostearate, liquid paraffin, white vaseline according to the above parts by weight, heat and melt, and keep warm at about 82°C to make the oil phase.

[0021] Dissolve the ethylparaben with an appropriate amount of hot water, add triethanolamine, sodium lauryl sulfate, and glycerin, and keep warm to about 80°C. Slowly add the oil phase into the water phase and stir until it solidifies, and then the O / W cream base is obtained for later use. T...

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PUM

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Abstract

The present invention discloses one kind of cream for treating alopecia. The cream is prepared with minoxidil, stearic acid, glycerol monostearate, white vaseline, propylene glycol, sodium thiosulfate, disodium edta, etc. The present invention adopts propylene glycol as both solvent and transdermal promoter, and sodium thiosulfate and disodium edta as antioxidants to prevent the oxidation of minoxidil, so as to result in even high treating effect. The cream of the present invention has obvious treating effect, no irritation, no hypersensitivity, low cost and other advantages, and is used in treating different kinds of alopecia.

Description

technical field [0001] The invention relates to a cream for treating alopecia and a preparation method thereof, belonging to the technical field of externally used medicines for treating alopecia. Background technique [0002] Alopecia is a kind of common disease, frequently-occurring disease, and there is constantly increasing tendency. In the prior art, there are also some medicines for treating hair loss, but there are problems such as poor hair growth effect, long course of treatment, and high price. Minoxidil (Minoxidil) is a kind of direct relaxation of smooth muscle, opening ATP-sensitive potassium channel and lowering blood pressure. It is the second or third-line drug for the treatment of hypertension. After taking it for more than one month, almost all patients will develop hirsutism side effect. This suggests that it can be used to treat alopecia. Based on this feature, we have repeatedly tested the drug from the preparation process to the clinical application, ...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61K9/06A61K47/44A61P17/14A61K47/14
Inventor 田应彪陈泽慧王敏何勇刘玉翠
Owner AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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