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Zhenqi dripping pill for strengthening resistance

A technology of Zhenqi Fuzheng and dripping pills, which is applied in the direction of pill delivery, plant raw materials, digestive system, etc., can solve the problems of affecting the effect of treatment, low bioavailability, low dissolution rate, etc., to improve bioavailability, dissolution and Accelerated absorption and increased stability

Inactive Publication Date: 2007-08-22
叶宏裕 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Other preparations based on this prescription include capsules, granules, etc. Due to preparation technology and other reasons, most oral preparations of traditional Chinese medicines have long dissolution time, low dissolution rate, and poor absorption after taking them. , low bioavailability and hepatoenteric first-pass effect
For example, granules have disadvantages such as high sugar content, strong hygroscopicity, and poor stability; capsules are easy to absorb moisture and agglomerate, and because they are 0 # Capsules, large in size, 6 capsules at a time, difficult to swallow, causing inconvenience to patients
These factors all affect the efficacy of various dosage forms of Zhenqi Fuzheng, and directly affect the effect of treatment.
At the same time, the selection of condensing agent in the existing drop pill preparation technology is also difficult to meet the forming requirements of large-scale drop pills, so it is impossible to prepare large-scale drop pills of more than 100 mg
Many traditional Chinese medicine dripping pill preparations have a single dose of more than 20 pills, which brings great inconvenience to patients.
Especially for elderly patients, it is very inconvenient

Method used

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  • Zhenqi dripping pill for strengthening resistance

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] 1. Preparation of the medicinal extract: take the two medicinal materials of Astragalus and Ligustrum lucidum to decoct three times, combine the decoction and filter, concentrate under reduced pressure, and spray-dried to obtain a dry extract powder.

[0031]2. Matrix: polyethylene glycol 4000, polyethylene glycol 6000, polyethylene glycol 4000 + polyethylene glycol 6000.

[0032] 3. Proportion: Take g or kg as the unit, in parts by weight, drug extract: matrix=1:1~1:3.

[0033] 4. Use a water bath, an oil bath or other heating methods to heat the mixture until a molten liquid and / or emulsion and / or suspension containing the drug extract and the matrix are obtained, and mix well.

[0034] 5. Using a special dropping pill machine, pre-set the required drop pill specifications, and adjust the temperature control system of the dropping pill machine to heat and maintain the temperature of the dripping pill machine at 50℃~90℃. The temperature cools and forms a temperature gradie...

example 1

[0038] Example 1: Choose different substrates, different ratios of dry powder and substrate, and choose different dripper temperatures for the prescription test

[0039] Experimental design: In order to observe the following conditions: 1. Choose different substrates, 2. Choose different ratios for the same substrate, 3. Choose different low head temperatures for the same substrate and the same ratio, to formulate the effects on the products involved in the present invention, respectively Polyethylene glycol-4000, polyethylene glycol 6000, polyethylene glycol 4000+polyethylene glycol 6000 and other bases are mixed with the raw material powder, respectively according to the raw material dry powder: matrix=1:1.5 / 1:2 / 1:2.5 The proportions of the others are in accordance with the conditions given in the [Specific implementation], using electric heating to heat the raw and auxiliary materials prepared in each group to a molten state, and using a dedicated dropping pill machine to adjus...

example 2

[0040] Example 2: Test of choosing different condensing agents in the preparation process

[0041] Experimental design: In order to observe the influence of different condensing agents selected during the preparation process on the products involved in the present invention, liquid paraffin, soybean oil, and methyl silicone oil were used as condensing agents, and the others were all in accordance with the conditions given in [Specific embodiments]. The matrix is ​​made of polyethylene glycol 4000 mixed with dry powder in a ratio of 2.5:1, and the raw and auxiliary materials prepared in each group are heated to the molten state by electric heating, and the special dripping machine is used to adjust the temperature of the dripper. Keep it at 85±2℃; adjust the refrigeration control system of the dropping pill machine to keep the temperature of the condensate at 20→-5℃, and then prepare separately according to the process given in the previous [Detailed embodiments], you can get 3 The...

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Abstract

The present invention is one kind of oral Chinese medicine preparation, Zhenqi dripping pill for strengthening resistance, prepared with astragalus root and privet fruit as main material. Zhenqi dripping pill for strengthening resistance has high bioavailability, fast acting and less toxic side effect. The present invention also provides the preparation process.

Description

Technical field [0001] The invention relates to a Zhenqi Fuzheng dripping pill preparation for replenishing qi and nourishing yin, which is used for chronic illness and deficiency, insufficient qi and yin, and cooperates with surgery, radiotherapy and chemotherapy to promote the recovery of normal functions. The preparation uses Astragalus and Ligustrum lucidum as the main raw materials, and is an oral dripping pill preparation made from Zhenqi Fuzheng capsule dosage form through dosage form modification. Background technique [0002] Over the years, many experts and scholars at home and abroad have noticed that certain disease patients, especially tumor patients, are accompanied by a certain degree of immune function decline, and immunosuppression is a condition for tumor occurrence and development. The performance is particularly obvious in patients undergoing chemotherapy or radiotherapy. The immune function of patients with malignant tumors is related to the prognosis. A good...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/20A61P1/14
Inventor 叶宏裕王伟
Owner 叶宏裕
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