Organic composite Chinese medicine immunopotentiator/adjuvant and its prepn process

A technology of immune enhancer and traditional Chinese medicine, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., which can solve the problems of endangering human health, difficulty in dissipating, and decline in carcass quality, so as to improve the survival rate and reduce the seriousness of the disease. extent, the effect of preventing the occurrence of disease

Inactive Publication Date: 2007-08-22
广东省家禽科学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to various reasons such as the high price of certain immune enhancers / adjuvants, most of them are still in the laboratory stage; chemical drug immune enhancers may reduce the production performance of the body to varying degrees, cause toxic side effects and drug residues, and endanger human health, etc. Disadvantages: Vaccine adjuvants are widely used and are mainly mineral oils. However, strong stress reactions are prone to occur after injection of oil vaccines, and because the mineral oil in oil adjuvants exists in the body for a long time because it cannot be metabolized, it often causes local tissue damage. Damage and formation of induration that is difficult to dissipate, these mineral oils that cannot be absorbed in livestock and poultry can easily cause carcass quality decline, and directly enter the human body through the food chain, seriously affecting people's health
In addition, in the prevention of poultry infectious diseases (such as fowl cholera and chicken Newcastle disease), there are also some explorations and reports of propolis adjuvant inactivated vaccines, but the adjuvant type is single, mostly pure propolis, and the prevention objects are chickens, ducks, and geese.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The raw material formula of Chinese medicine compound immunostimulant / adjuvant is (proportioning by weight):

[0049] 1 part of Astragalus, 1 part of Fufangteng, 1 part of Codonopsis, 1 part of Ganoderma lucidum, 0.01 part of pure propolis.

[0050] Preparation of traditional Chinese medicine compound immune enhancer / adjuvant:

[0051] 1. Soak pure propolis with 95% ethanol to make propolis tincture containing 98% propolis;

[0052] 2. Decoct Astragalus, Fufangteng, Codonopsis and Ganoderma lucidum twice in water, 2-3 hours each time, combine the decoction, filter, concentrate the filtrate under reduced pressure, and then carry out ethanol precipitation treatment twice, and dilute alcohol After the ethanol was recovered from the extract, water for injection was added to the resultant (when preparing an immune adjuvant, add 5 parts of water for injection per part by weight of the product, and when preparing an immune enhancer, add 12 parts of water for injection per par...

Embodiment 2

[0058] The raw material formula of Chinese medicine compound immunostimulant / adjuvant is (proportioning by weight):

[0059] 3 parts of astragalus, 3 parts of fufangteng, 3 parts of ginseng, 3 parts of codonopsis, 3 parts of ganoderma, 3 parts of berberine, 3 parts of honeysuckle, 3 parts of forsythia, 0.03 parts of pure propolis.

[0060] Preparation of traditional Chinese medicine compound immune enhancer / adjuvant:

[0061] 1. Soak pure propolis with 95% ethanol to make propolis tincture containing 98% propolis;

[0062] 2. Decoct astragalus, fufangteng, ginseng, codonopsis, ganoderma, coptis, honeysuckle and forsythia twice in water for 2 to 3 hours each time, combine the decoctions, filter, concentrate the filtrate under reduced pressure, and then After ethanol precipitation treatment for 2 times, after the ethanol was recovered from the alcohol extract, water for injection was added to the resultant (when preparing an immune adjuvant, add 8 parts of water for injection p...

Embodiment 3

[0067] The raw material formula of Chinese medicine compound immunostimulant / adjuvant is (proportioning by weight):

[0068] 1 part of Astragalus, 1 part of Fufangteng, 2 parts of Codonopsis, 2 parts of Ganoderma lucidum, 1 part of Coptis chinensis, 1 part of honeysuckle, 0.02 part of pure propolis.

[0069] Preparation of traditional Chinese medicine compound immune enhancer / adjuvant:

[0070] 1. Soak pure propolis with 95% ethanol to make propolis tincture containing 98% propolis;

[0071] 2. Decoct Astragalus, Fufangteng, Codonopsis pilosula, Ganoderma lucidum, Coptis chinensis, honeysuckle and Forsythia 2 times in water, 2 to 3 hours each time, combine the decoctions, filter, concentrate the filtrate under reduced pressure, and then pass through ethanol Precipitation is processed 2 times, after the ethanol is recovered from the alcohol extract, water for injection is added to the resultant (when preparing an immune adjuvant, add 6 parts of water for injection per part by ...

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PUM

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Abstract

The present invention proposes one kind of organic composite Chinese medicine immunopotentiator/adjuvant for preventing and treating animal contagious diseases and its preparation process. The Chinese medicine immunopotentiator/adjuvant is prepared with propolis and eight kinds of Chinese medicinal materials, including astragalus root, fortune euonymus stem or leaf, Dangshen, glossy ganoderma, ginseng, etc. and through compounding the extracted liquid of the Chinese medicinal materials and the alcohol leaching liquid of propolis. It can enhance the immunity of available vaccine and strengthen animal's disease resistance.

Description

technical field [0001] The invention relates to a pure traditional Chinese medicine compound immune enhancer / adjuvant for preventing and treating livestock and poultry infectious disease vaccines and a preparation method thereof. Background technique [0002] Infectious diseases of livestock and poultry are diseases that seriously endanger the production of livestock and poultry. It can not only cause a large number of deaths of livestock and poultry, reduce the performance of livestock and poultry production, and reduce the quality of livestock and poultry products, which directly affects the economic income and foreign trade of farmers and herdsmen. Illness also threatens human health. At present, the prevention and treatment of infectious diseases relies more on the immunization of various vaccines (bacteria) and the use of drugs. In particular, immune cells such as lymphocytes and macrophages are in a depressed or suppressed state; coupled with the continuous emergence ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K39/39A61P37/04A61P31/14A61K35/64A61K35/644
Inventor 邹永新
Owner 广东省家禽科学研究所
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