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Hippophate flavone powder capsule and its preparing method

A seabuckthorn flavone and soft capsule technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as the increase in the prevalence of cardiovascular and cerebrovascular diseases, improve blood rheology, and inhibit platelet aggregation. , Improve the effect of myocardial circulation

Inactive Publication Date: 2007-08-29
XINMA MEDICINE SCI TECH SHENYANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, although there are many cardiovascular and cerebrovascular drugs in clinical application, which have played a good role in the treatment of cardiovascular and cerebrovascular diseases, they have not been able to curb the growth of the prevalence of cardiovascular and cerebrovascular diseases. It reflects the need for continuous efforts to develop more effective new drugs and put them into clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Composition of medicinal liquid materials: seabuckthorn flavonoid fine powder 60g, soybean oil 200g, beeswax 8g

[0019] Capsule shell material composition: 100g of gelatin, 43g of glycerin, 102g of water, 0.18g of methyl paraben, and 0.1g of ethyl paraben.

[0020] Preparation method: (1) Capsule content preparation: Put beeswax in soybean oil, heat until melted, let cool to room temperature, add seabuckthorn flavonoids, stir well with a colloid mill to obtain a medicinal solution;

[0021] (2) Capsule shell preparation Add gelatin, glycerin, and water to the stainless steel jacketed pot in turn, stir and granulate under vacuum, and make loose and uniform granules for about 15 minutes. Open the cover under normal pressure, and add the washed Net glue, back glue and 20% ethanol solution of methylparaben and paraben hexyl, stirred and heated under vacuum for 5 to 2 hours at a temperature of 70 to 75°C to melt them all, and continued to concentrate under reduced pressure ...

Embodiment 2

[0024] Composition of medicinal liquid materials: seabuckthorn flavonoid fine powder 60g, peanut oil 210g, beeswax 8g

[0025] Capsule shell material composition: 100g of gelatin, 43g of glycerin, 102g of water, 0.18g of methyl paraben, and 0.1g of ethyl paraben.

[0026] Preparation method: pressing soft capsules Firstly, adjust the environmental conditions of the pill pressing room to achieve constant temperature and humidity, usually the temperature is 25°C and the relative humidity is 35%. The filtered glue liquid enters the capsule making machine, adjusts the oil shaft and the drum, so that the thickness of the pressed tape is 0.3mm, and at the same time, the seabuckthorn flavonoid liquid flows from the liquid storage tank through the filling pump, and enters the rolling die to fill the tape until Ellipse-shaped soft capsules are made by rolling die spinning, and the weight of each capsule is adjusted to 0.5g.

[0027] Drying of soft capsules The soft capsules coming dow...

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Abstract

The present invention discloses a hippophae rhmnoides flavone soft capsule and its preparation method. The invented hippophae rhmnoides flavone soft capsule is formed from two portions of content material and capsule shell. Its content material is composed of hippophae rhmnoides flavone, vegetable oil and bee's wax, and its capsule shell is made up by using gelatin, water, glycerine and preserving agent. Said hippophae rhmnoides flavone soft capsule can obtain good therapeutic effect for curing the diseases of hypertension, hyperlipemia, coronary heart disease and other angiocardipathy and cerebrovascular disease.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation of seabuckthorn flavonoids, more specifically to a seabuckthorn flavonoid soft capsule, and simultaneously the invention also relates to a preparation method of the preparation. Background technique [0002] Cardiovascular disease and cerebrovascular disease are recognized as two major enemies that endanger human health and survival. According to national statistics in 1996, cardiovascular disease (CVD) caused about 15.5 million deaths, accounting for 30% of the global death toll due to disease in that year. %. It accounts for 45.6% of the total deaths in developed countries and 24.5% of the total deaths in developing countries. Among the main causes of death due to diseases, coronary heart disease and cerebrovascular disease ranked first and second respectively with 7.2 million and 4.6 million people in 1996. Experts pointed out that smoking, hyperlipidemia, high blood pressure, abnormal blood su...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/48A61K31/7048A61P3/06A61P9/06A61P9/10A61P37/04A61P1/16A61P11/00A61P17/16A61K31/352
Inventor 李献阳
Owner XINMA MEDICINE SCI TECH SHENYANG
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