Ginkgolide B powder injection and its preparation method

Abstract

The invention discloses a Ginkgolide B powder injection, which is characterized in that: it is a powder injection consisting of main medcine and pharmacological acceptable filter aid, excipient and stabilizer. Said main medicine is Ginkgolide B, and filter aid is meglumine, and excipient is mannitol or dextran 40, and stabilizer is EDTA-2Na or EDTA-CaNa. The weight ratio is: Ginkgolide B:EDTA-2Na or EDTA-CaNa:mannitol or dextran 40 = 1:0.5-3:0.01-2:1-20. The preparation solves the problems such as Ginkgolide B indissolvable problem, redissolve clarity and stability.

Description

technical field

[0001] The invention relates to a drug monomer ginkgolide B obtained by extracting the leaves of the traditional Chinese medicine ginkgo biloba, as well as a ginkgolide B powder injection prepared from the drug and a preparation method thereof. Background technique

[0002] Platelet activating factor (PAF) is an important inflammatory mediator and one of the mediators of various diseases. Pathological studies have shown that PAF plays an important role in processes such as allergy, ulcer, asthma, thrombosis, inflammation, organ transplant rejection, and shock caused by endotoxin. Total ginkgolides are a combination of ginkgolides A, B, C and bilobalide, the active ingredients extracted from ginkgo leaves, and are a strong antagonist of platelet activating factor from plant extracts. Studies have shown that among them, total ginkgolide B is the most active platelet activating factor antagonist.

[0003] The structural formula of ginkgolide B is:

[0004] ...

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